血府逐瘀汤联合宁心宝胶囊治疗非瓣膜性房颤血栓栓塞的疗效观察  

Clinical Observation of Xuefu Zhuyu Decoction(血府逐瘀汤)Combined with Ningxinbao Capsule(宁心宝胶囊)in Treatment of Non-Valvular Atrial Fibrillation Thromboembolism

作　　者：朱佳 杨宁 靳明晨 乔春友 王晓微 刘静雅 ZHU Jia;YANG Ning;JIN Mingchen;QIAO Chunyou;WANG Xiaowei;LIU Jingya(General Global China Railway Shanqiao Hospital,Qinhuangdao 066200,Hebei,China;Zhangjiakou First Hospital,Zhangjiakou 075041,Hebei,China)

机构地区：[1]通用环球中铁山桥医院,河北秦皇岛066200 [2]张家口市第一医院,河北张家口075041

出　　处：《辽宁中医杂志》2023年第9期94-98,共5页Liaoning Journal of Traditional Chinese Medicine

基　　金：河北省中医药管理局科研计划项目(2022527)。

摘　　要：目的探究血府逐瘀汤联合宁心宝胶囊治疗非瓣膜性心房颤(non-valvular atrial fibrillation,NVAF)血栓患者的治疗效果。方法选取2019年8月—2021年5月在该院接受治疗的NVAF血栓患者94例,采用随机数表法分为观察组和对照组,分别有患者49例、45例。对照组患者采用常规西药治疗,观察组患者采用血府逐瘀汤联合宁心宝胶囊治疗,对比两组治疗效果。结果观察组总有效率为89.80%(44/49),高于对照组的68.89%(31/45)(P<0.05);治疗前,两组患者的中医证候心前区疼痛、唇色、舌色、脉搏评分均差异无统计学意义(P>0.05);治疗后,两组上述参数均降低(P<0.05),观察组治疗后评分均低于对照组(P<0.05);治疗前,两组患者的凝血功能指标(prothrombin time,PT)、活化部分凝血活酶时间(activated partial thromboplastin time,APTT)、国际标准化比值(international normalized ratio,INR)均差异无统计学意义(P>0.05);治疗后,两组上述参数均增大(P<0.05),观察组治疗后评分均高于对照组(P<0.05);治疗前,两组患者的循环内皮细胞(circulating endothelial cells,CEC)、内皮素-1(endothelin-1,ET-1)水平均差异无统计学意义(P>0.05);治疗后,两组CEC、ET-1均下降,观察组治疗后上述指标低于对照组(P<0.05);治疗前,两组患者心功能指标的左室射血分数(left ventricular ejection fraction,LVEF)、心输出量(cardiac output,CO)均差异无统计学意义(P>0.05);治疗后,观察组的上述参数较均高于对照组(P<0.05);治疗前,两组患者血友病因子(von Willebrand Factor,vWF)、C反应蛋白(C-reaction protein,CRP)、血栓素B_(2)(thromboxane B_(2),TXB_(2))差异无统计学意义(P>0.05);治疗后,观察组血清vWF、CRP、TXB2均显著低于对照组(P<0.05)。结论非瓣膜性心房颤合并血栓患者采用血府逐瘀汤联合宁心宝胶囊治疗,可有效提升临床疗效,改善患者血管内皮功能,进而促进患者心功能及血栓情况好转,且对凝血功能影响较小。Objective To explore the therapeutic effect of Xuefu Zhuyu Decoction(血府逐瘀汤)combined with Ningxinbao Capsule(宁心宝胶囊)in the treatment of non-valvular atrial fibrillation(NVAF)thrombosis patients.Methods A total of 94 patients with NVAF thrombosis who were treated in the hospital from August 2019 to May 2021 were selected and divided into an observation group and a control group by random number table method,with 49 patients and 45 patients,respectively.The patients in the control group were treated with conventional western medicine,and those in the observation group were treated with Xuefu Zhuyu Decoction combined with Ningxinbao Capsule and the therapeutic effects of the two groups were compared.Results The total effective rate in the observation group was 89.80%(44/49),which was higher than 68.89%(31/45)in the control group(P<0.05).Before treatment,there were no differences in TCM syndromes of precordial pain,lip color,tongue color and pulse score between the two groups(P<0.05).After treatment,the above parameters in the two groups were decreased(P<0.05),and the scores in the observation group after treatment were lower than those in the control group(P<0.05).There was no difference in(international normalized ratio,INR)(P>0.05).After treatment,the above parameters in the two groups increased(P<0.05),and the scores in the observation group after treatment were higher than those in the control group(P<0.05).There was no difference in the levels of circulating endothelial cells(CEC)and endothelin-1(ET-1)(P>0.05).After treatment,CEC and ET-1 in the two groups decreased,and the above indicators in the observation group were lower than those in the control group after treatment(P<0.05).There were no differences in LVEF or CO of functional indicators(P>0.05).After treatment,the above parameters in the observation group were higher than those in the control group(P<0.05).Before treatment,there was no difference in serum von Willebrand factor(vWF),C-reaction protein(CRP)and thromboxane B_(2)(TXB_(2))b

关 键 词：血府逐瘀汤 宁心宝胶囊 非瓣膜性房颤 血栓栓塞 

分 类 号：R543.31[医药卫生—心血管疾病]