解郁天香丹对冠心病伴抑郁焦虑障碍患者IL-6表达及生活质量影响的临床研究  

Effect of Jieyu Tianxiang Dan(解郁天香丹)on Expression of IL-6 and Quality of Life in Patients with Coronary Heart Disease and Depression and Anxiety Disorder

作　　者：谢林园 赵明芬[2] 倪昀 XIE Linyuan;ZHAO Mingfen;NI Yun(Xinjiang Second Medical College,Urumqi 830000,Xinjiang,China;Traditional Chinese Medicine Hospital Affiliated to Xinjiang Medical University,Urumqi 830000,Xinjiang,China;Xinjiang Uygur Autonomous Region Occupational Disease Hospital,Urumqi 830000,Xinjiang,China)

机构地区：[1]新疆第二医学院,新疆乌鲁木齐830000 [2]新疆医科大学附属中医医院,新疆乌鲁木齐830000 [3]新疆维吾尔自治区职业病医院,新疆乌鲁木齐830000

出　　处：《辽宁中医杂志》2023年第9期102-107,共6页Liaoning Journal of Traditional Chinese Medicine

基　　金：国家自然科学基金项目(82160876);新疆维吾尔自治区重点实验室开放课题(2018D04023)。

摘　　要：目的观察解郁天香丹对冠心病伴抑郁焦虑障碍患者白细胞介素-6(IL-6)及超敏C反应蛋白(hs-CRR)的表达及生活质量的影响。方法选择就诊新疆医科大学附属中医医院且符合标准的患者60例,随机分为观察组和对照组,每组30例,两组均用阿司匹林肠溶片及阿托伐他汀基础治疗,对照组加用黛力新治疗,观察组加用中药解郁天香丹治疗,疗程均为4周。比较两组治疗前后炎症指标IL-6、hs-CRR变化情况以及综合医院焦虑抑郁评分量表(HAD)、中医证候积分、生活质量评定量表简表(WHOQOL-BREF)变化。并收集两组患者在观察时间内的不良反应进行比较。结果两组患者在治疗后,两组患者经治疗后IL-6较治疗前明显改善(P<0.05);观察组患者IL-6较对照组降低明显(P<0.05);观察组患者经治疗后hs-CRP较治疗前明显改善(P<0.05),两组hs-CRP差异无统计学意义(P>0.05)。焦虑、抑郁均有所改善,观察组优于对照组(P<0.05)。在中医证候方面,观察组的有效率为86.7%(26/30),高于对照组有效率为70.0%(21/30)。在中医症状方面,两组患者在胸痛、胸闷、失眠多梦均有所改善,且观察组优于对照组(P<0.05)。两组患者治疗后生活质量均有所改善,且观察组在生理、心理方面优于对照组(P<0.05)。观察组心电图有效率86.7%(26/30),高于对照组66.7%(20/30)。两组患者在治疗前后的不良反应对比,观察组0例,小于对照组7例。两组的安全指标,差异不具有统计学意义(P>0.05)。结论解郁天香丹治疗冠心病伴抑郁焦虑障碍在改善患者焦虑、抑郁、中医临床证候、生活质量疗效显著,能明显降低炎症指标IL-6。用药安全且药物无不良反应,具有较高临床价值,值得推广应用。Objective To observe the effect of Jieyu Tianxiang Dan(解郁天香丹)on the expressions of interleukin-6(IL-6)and hypersensitivity C-reaction protein(hs-CRR)and the quality of life in patients with coronary heart disease and depression and anxiety disorder.Methods Sixty patients were randomly divided into observation group and control group(30 cases in each group).Both groups were treated with aspirin enteric-coated tablets and atorvastatin,the control group was treated with deanxit and the observation group was treated with Jieyu Tianxiang Dan for four weeks.The changes of IL-6 and hs-CRR in the two groups before and after treatment were compared,and the General Hospital anxiety and depression rating scale(HAD),TCM symptom scores,quality of life rating scale(WHOQOL-BREF)changes were observed.The adverse reactions of the two groups in the observation time were compared.Results After treatment,the levels of IL-6 in the two groups were significantly improved(P<0.05),the levels of IL-6 in the observation group were significantly lower than those in the control group(P<0.05),and the levels of hs-CRP in the observation group were significantly improved(P<0.05),but there was no significant difference between the two groups(P>0.05).Anxiety and depression were improved.The observation group was better than the control group(P<0.05).In TCM syndrome,the effective rate of the observation group was 86.7%(26/30),higher than that(70.0%,21/30)of the control group.In TCM symptoms,chest pain,chest tightness and insomnia were improved in both groups,and the observation group was better than the control group(P<0.05).The quality of life of the two groups was improved after treatment,and the observation group was better than the control group in physiology and psychology(P<0.05).The effective rate of electrocardiogram(ECG)in the observation group was 86.7%(26/30),higher than that(66.7%,20/30)in the control group.The adverse reactions of the two groups before and after treatment were compared.There was 0 case with adverse reaction

关 键 词：解郁天香丹 冠心病 抑郁焦虑 临床对照研究 

分 类 号：R541.4[医药卫生—心血管疾病]