自拟调胃饮加减治疗小儿慢性胃炎的临床研究  

Clinical Study on Self-Made Modified Tiaowei Decoction(自拟调胃饮)in Treatment of Children with Chronic Gastritis

作　　者：李静 米延强 武进华 LI Jing;MI Yanqiang;WU Jinhua(Department of Traditional Chinese Medicine Pediatrics,Yan'an Hospital of Traditional Chinese Medicine,Yan'an 716000,Shaanxi,China;Department of Pediatrics,Shaanxi Provincial Hospital of Traditional Chinese Medicine,Xi'an 710003,Shaanxi,China)

机构地区：[1]延安市中医医院中医儿科,陕西延安716000 [2]陕西省中医医院儿科,陕西西安710003

出　　处：《辽宁中医杂志》2023年第10期104-107,共4页Liaoning Journal of Traditional Chinese Medicine

摘　　要：目的探讨自拟调胃饮加减治疗小儿慢性胃炎的效果。方法选取2019年8月—2021年7月医院收治的110例慢性胃炎患儿为研究对象,采用随机数表法分为观察组56例及对照组54例,对照组给予常规治疗,观察组在对照组治疗基础上给予自拟调胃饮加减治疗,对比两种治疗方式在小儿慢性胃炎中的治疗效果。结果观察组治疗总有效率与对照组比较,差异有统计学意义(P<0.05);治疗后两组白细胞介素-6(IL-6)、IL-8、肿瘤坏死因子(TNF-α)、胃泌素(GAS)、CD_(8)^(+)水平均显著降低,生长抑素(SS)、表皮生长因子(EGF)、CD_(3)^(+)、CD_(4)^(+)升高,且观察组治疗后IL-6、IL-8、TNF-α、GAS、CD_(8)^(+)水平均明显低于对照组,SS、EGF、CD_(3)^(+)、CD_(4)^(+)高于对照组(P<0.05);治疗后两组食欲减退、胃脘疼痛、胃部灼热、脘腹胀满、神疲倦怠、大便稀溏、口干口臭、烧心泛酸评分均显著降低,且观察组治疗后以上评分均明显低于对照组(P<0.05);两组不良反应发生率比较差异无统计学意义(P>0.05)。结论自拟调胃饮加减治疗小儿慢性胃炎效果较佳,可显著改善患者中医证候及胃肠激素,降低炎症因子水平,安全有效,值得在临床推广。Objective To investigate the effect of self-made Modified Tiaowei Decoction(自拟调胃饮)in the treatment of chronic gastritis in children.Methods A total of 110 children with chronic gastritis admitted to the hospital between August 2019 and July 2021 were selected as the research subjects.They were divided into observation group(56 cases)and control group(54 cases)by random number table method.The control group was given conventional treatment,and the observation group was treated with self-made Modified Tiaowei Decoction on this basis.The therapeutic effects of the two treatment methods on children with chronic gastritis were compared.Results There was a statistically significant difference in the total treatment response rate between the two groups(P<0.05).After treatment,the levels of interleukin-6(IL-6),interleukin-8(IL-8),tumor necrosis factor(TNF-α),gastrin(GAS)and CD_(8)^(+) were significantly reduced,while the levels of somatostatin(SS),epidermal growth factor(EGF),CD_(3)^(+) and CD_(4)^(+) were increased in the two groups.Meanwhile,the levels of IL-6,IL-8,TNF-α,GAS and CD_(8)^(+) in the observation group were significantly lower than those in the control group,and the levels of SS,EGF,CD_(3)^(+) and CD_(4)^(+) were higher than those in the control group(P<0.05).After treatment,the scores of loss of appetite,epigastric pain,heartburn,abdominal distension,fatigue,loose stools,dry mouth and bad breath and acid regurgitation of the two groups were significantly reduced,and the scores of the observation group were significantly lower than those of the control group(P<0.05).There was no statistically significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion Self-made Modified Tiaowei Decoction is safe and effective in the treatment of chronic gastritis in children.It can significantly improve TCM symptoms and gastrointestinal hormones and reduce the levels of inflammatory factors.

关 键 词：自拟调胃饮 加减 小儿 慢性胃炎 

分 类 号：R272[医药卫生—中医儿科学]