人尿中11种内分泌干扰物与甲状腺癌的关联性  

Associations of a mixture of eleven endocrine disruptors in human urine with the risk of papillary thyroid cancer

作　　者：毛慧超 张磊 李敬光 赵云峰 吴永宁 倪松 Mao Huichao;Zhang Lei;Li Jingguang;Zhao Yunfeng;Wu Yongning;Ni Song(Zouping County Center for Disease Control and Prevention,Binzhou 256209,China;NHC Key Lab of Food Safety Risk Assessment,China National Center for Food Safety Risk Assessment(CFSA),Beijing 100022,China;National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing 100021,China)

机构地区：[1]邹平市疾病预防控制中心,滨州256209 [2]国家食品安全风险评估中心,国家卫生健康委员会食品安全风险评估重点实验室,北京100022 [3]国家癌症中心,国家肿瘤临床医学研究中心,中国医学科学院北京协和医学院肿瘤医院,北京100021

出　　处：《卫生研究》2023年第6期986-992,共7页Journal of Hygiene Research

基　　金：国家自然科学基金(No.21976046,21507018)。

摘　　要：目的分析人体11种内分泌干扰物(endocrine disruptors,EDCs)混合暴露与乳头状甲状腺癌(papillary thyroid cancer,PTC)发病风险关联性,识别贡献最高的化合物。方法以空腹晨尿样品中11种EDCs含量表征机体暴露水平,采用Logistic回归检验EDCs与PTC关系,采用贝叶斯核函数回归检验混合暴露与PTC关系,采用加权分位数和(weighted quantile sum,WQS)回归和套索(least absolute shrinkage and selection operator,LASSO)回归识别贡献最大的化合物。结果多因素Logistic回归模型中,校正系列变量后,11种EDCs均与PTC发病风险存在关联且具有统计学意义(P<0.05);进一步考察混合暴露效应,其含量与PTC发病风险呈正相关且具有统计学意义(P<0.05);WQS回归和LASSO回归分析结果显示,单(2-乙基-5-羟基己基)邻苯二甲酸酯的贡献最大,其权重和回归系数分别为0.62和1.58。结论人体暴露于多种EDCs混合物会促进PTC发病风险,其中单(2-乙基-5-羟基己基)邻苯二甲酸酯的贡献最大。OBJECTIVE To examine the associations of human exposure to a mixture of 11 endocrine disruptors(EDCs)with the risk of papillary thyroid cancer(PTC),and to identify the priority of these EDCs.METHODS EDCs were determined in fasting urine specimens to represent human exposure.Logistics regressions were performed to examine the associations between individual EDC and PTC risk.Bayes kernel machine regression was applied to examine the associations between the mixture of EDCs and PTC risk.Weighted quantile sum(WQS)regression and LASSO regression were performed to identify the main contributor.RESULTS In the multivariate logistic regression model,after adjusting for a series of variables,11 endocrine disruptors were statistically significantly correlated with the risk of PTC(P<0.05).In BKMR models,the mixture of EDCs was positively correlated with the risk of PTC(P<0.05).The weight and coefficient of mono(2-ethyl-5-hydroxyhexyl)phthalate(MEHHP)was 0.62 and 1.58 in WQS and LASSO models,respectively,which were much higher than those of the other EDCs.CONCLUSION Combined exposure to o a variety of EDCs might promote the risk of PTC,and MEHHP was identified as the main contributor.

关 键 词：内分泌干扰物 乳头状甲状腺癌 混合暴露 病例-对照研究 

分 类 号：R12[医药卫生—环境卫生学] R581[医药卫生—公共卫生与预防医学]