高氧与未成熟脑损伤的研究进展  

Research advance in the relationship between hyperoxia and immature brain injury

作　　者：武童 冀红[1] WU Tong;JI Hong(Department of Pediatrics,The First Affiliated Hospital of Dalian Medical University,Dalian,Liaoning 116000,China)

机构地区：[1]大连医科大学附属第一医院儿科,辽宁大连116000

出　　处：《中国儿童保健杂志》2023年第11期1214-1218,1240,共6页Chinese Journal of Child Health Care

摘　　要：随着新生儿重症监护取得巨大进展,早产儿的存活率明显提高,高氧治疗在新生儿尤其是在早产儿早期治疗中发挥着关键的作用,但超生理浓度的氧对发育中的肺和视网膜都有着严重危害。不仅如此,在临床及实验工作中,高氧引起的氧化应激状态导致的永久性神经损伤逐渐被重视,尤其是在脑发育尚不完全的早产儿中,这种损害给患儿及其家庭带来沉重的负担。本文就高氧对未成熟脑的损伤机制及其潜在治疗策略进行综述。With significant progress being made in neonatal intensive care,the survival rate of premature infants has been substantially increased.Hyperoxia therapy plays a key role in the early treatment of neonates,especially in premature infants.However,supraphysiological concentration of oxygen has toxic effects on the developing lung and retina.Moreover,permanent neurological impairments caused by oxidative stress induced by hyperoxia have been paid more and more attention,especially in premature infants with incomplete brain development,which brings heavy burden to children and their families.This article reviews the mechanism of hyperoxia on immature brain injury and its potential treatment strategies.

关 键 词：高氧 氧化应激 脑损伤 新生儿 

分 类 号：R722[医药卫生—儿科]