尿镉与桥本甲状腺炎的相关性分析:一项基于NHANES的横断面研究  

Correlation analysis between urinary cadmium and Hashimoto’s Thyroiditis:a cross-sectional study based on NHANES

作　　者：闫少帅 于旭东 丁治国 户蕊 李璐[1] 刘晓訸 商建伟[1] YAN Shao-shuai;YU Xu-dong;DING Zhi-guo;HU Rui;LI Lu;LIU Xiao-he;SHANG Jian-wei(Dongzhimen Hospital,Beijing University of Chinese Medicine,Beijing 100700,China;不详)

机构地区：[1]北京中医药大学东直门医院,北京100700 [2]北京中医药大学孙思邈医院

出　　处：《现代预防医学》2023年第20期3812-3817,共6页Modern Preventive Medicine

基　　金：中医药“双链融合”中青年科研创新团队建设项目(2022-SLRH-LJ-005);陕西省科学技术厅重点产业创新链(群)-社会发展领域(2023-ZDLSF-56);铜川市甲状腺病防治中心2022年度中医药科研专项(TJF-2022-05);铜川市甲状腺病防治中心2022年度中医药科研专项(TJF-2022-06)。

摘　　要：目的本研究首次通过探究尿镉和桥本甲状腺炎(HT)之间的潜在关系,为HT的预防和控制提供依据。方法基于2007—2012年NHANES数据库,纳入4754例同时具有尿镉浓度指标和甲状腺过氧化物酶抗体(TPOAb)或甲状腺球蛋白抗体(TgAb)数据的人群。采用逻辑回归模型探讨尿镉与HT的关系,并且针对年龄和性别进行亚组分析。结果患有HT人群的尿镉浓度(0.27μg/L)明显高于正常人群(0.24μg/L),且差异具有统计学意义(Z=5.542,P<0.001)。此外,在校正混杂因素后,尿镉每上升一个四分位数,HT的患病风险增加13.4%(OR=1.134,95%CI:1.009~1.274),且HT的患病风险随着尿镉的分位数增加而逐步增加(P趋势=0.032)。结论镉可能是HT的危险因素,并且在女性和中老年人群中这种相关性可能更加明显。Objective To explore the potential relationship between urinary cadmium and Hashimoto’s Thyroiditis(HT),and to provide a basis for the prevention and control of HT.Methods Based on the 2007—2012 NHANES database,4754 cases with both urinary cadmium concentration indicators and thyroid peroxidase antibody(TPOAb)or thyroglobulin antibody(TgAb)data were included.A logistic regression model was used to explore the association between urinary cadmium and Hashimoto’s thyroiditis.And then subgroup analyses were performed for age and sex.Results Urinary cadmium concentrations were significantly higher in people with HT(0.27μg/L)than in normal people(0.24μg/L)and the difference was statistically significant(Z=5.542,P<0.001).Furthermore,after correcting for confounders,the risk of developing HT increased by 13.4%for each quartile of urinary cadmium(OR=1.134,95%CI:1.009-1.274),and the risk of developing HT increased progressively with the quartile of urinary cadmium(Ptrend=0.032).Conclusion Cadmium may be a risk factor for HT,and this association may be more pronounced in women and middle-aged and elderly populations.

关 键 词：桥本甲状腺炎 桥本病 NHANES 镉 

分 类 号：R581.4[医药卫生—内分泌]