CCAAT增强子结合蛋白β在骨关节炎中对基质金属蛋白酶表达调控的研究进展  

Research progress of C/EBPβ regulating MMPs expression in osteoarthritis

作　　者：王泽宇 梁志宇 吴龙火[2] 王妙飞[2] 施伟梅[2] WANG Ze-yu;LIANG Zhi-yu;WU Long-huo;WANG Miao-fei;SHI Wei-mei(Rehabilitation School of Gannan Medical University;School of Pharmacy,Gannan Medical University,Ganzhou,Jiangxi 341000)

机构地区：[1]赣南医学院康复学院 [2]赣南医学院药学院,江西赣州341000

出　　处：《赣南医学院学报》2023年第9期918-922,共5页JOURNAL OF GANNAN MEDICAL UNIVERSITY

基　　金：江西省教育厅科学技术研究项目(GJJ211505)。

摘　　要：骨关节炎是一种常见的关节退行性疾病,其发生机制复杂,目前尚未明确。研究发现,基质金属蛋白酶(Matrixmetallo proteinases,MMPs)的增多可引起骨关节炎中软骨细胞外基质降解进而导致进行性关节软骨受损,MMPs是诱导骨关节炎发病进程的主要因素,MMPs的表达受到多种因素调控。研究表明,CCAAT增强子结合蛋白β(CCAAT enhancer-binding protein-beta,C/EBPβ)作为一种转录因子在调控MMPs表达的过程中发挥着重要作用。本文就骨关节炎中C/EBPβ对基质金属蛋白酶家族的表达调控进行综述,以期为骨关节炎的防治提供新的研究思路。Osteoarthritis is a common joint degenerative disease,and its mechanism is complex and not yet clear.It was found that an increase in matrix metalloproteinases(MMPs)can cause degradation of the cartilage extracellular matrix in osteoarthritis leading to progressive articular cartilage damage.MMPs are believed to be a major factor in the pathogenesis of osteoarthritis,and their expression is regulated by a number of factors.Studieshave shown that C/EBPβ(CCAAT enhancer-binding protein-beta),a transcription factor,plays an important role in regulating the expression of MMPs.This review provides a brief overview on the regulation of matrix metalloproteinase family expression by C/EBPβin osteoarthritis,with the aim of providing new research ideas for the prevention and treatment of osteoarthritis.

关 键 词：骨关节炎 CCAAT增强子结合蛋白β 关节软骨 细胞外基质 基质金属蛋白酶 

分 类 号：R684.3[医药卫生—骨科学]