山姜属二苯基庚烷类化合物及其生物活性研究进展  

Research Progress on Diarylheptanoids of Alpinia Genus and Their Biological Activity

作　　者：李承哲 彭成[1] 周勤梅[1,2,3] 刘菲 熊亮 Li Chengzhe;Peng Cheng;Zhou Qinmei;Liu Fei;Xiong Liang(State Key Laboratory of Southwestern Chinese Medicine Resources,School of Pharmacy,Chengdu University of Traditional Chinese Medicine,Chengdu,611137,China;Institute of Innovative Medicine Ingredients of Southwest Specialty Medicinal Materials,Chengdu University of Traditional Chinese Medicine,Chengdu,611137,China;Innovative Institute of Chinese Medicine and Pharmacy,Chengdu University of Traditional Chinese Medicine,Chengdu,611137,China)

机构地区：[1]成都中医药大学药学院、西南特色中药资源国家重点实验室,四川成都611137 [2]成都中医药大学、西南特色药材创新药物成分研究所,四川成都611137 [3]成都中医药大学中医药创新研究院,四川成都611137

出　　处：《成都中医药大学学报》2023年第5期57-65,共9页Journal of Chengdu University of Traditional Chinese Medicine

基　　金：国家自然科学基金项目(81903777、82104371、82022072);四川省青年科技创新研究团队专项计划项目(2017TD0001)。

摘　　要：山姜属(Alpinia)为姜科中药的主要药用植物来源,该属包含高良姜、益智、草豆蔻等多种传统中药。目前,研究者从山姜属的药用植物中发现数量众多且结构新颖的二苯基庚烷类化合物,该类型化合物是山姜属植物的代表性成分类型之一,其具有广泛的药理活性,包括抗氧化、抗肿瘤、抗炎、降血糖、抗病毒等。本文对山姜属中二苯基庚烷类化合物的结构和生物活性进行了总结,以化合物类型对结构进行分类,归纳讨论了无环直链二苯基庚烷、环氧二苯基庚烷、二苯基庚烷二聚体、二苯基庚烷-单萜聚合体和二苯基庚烷-黄酮聚合体的结构特征和他们的主要药理作用,以期为该属植物的开发利用提供参考。Genus Alpinia is the main medicinal plant source of Zingiberaceae traditional Chinese medicine,which includes A.officinarnm,A.oxypnylla,A.katsumadai and other traditional Chinese medicines.At present,researchers have discovered a large number of novel diarylheptanoids from medicinal plants of the Alpinia genus.This type of compound is one of the representative components of Alpinia genus and has a wide range of pharmacological activities,including anti-oxidation,anti-tumor,anti-inflammation,hypoglycemia,anti-virus,etc.The structure and biological activity of diarylheptanoids in Alpinia are summarized,the structural characteristics and main pharmacological activities of acyclic diarylheptanoids,epoxy diarylheptanoids,diarylheptanoid dimers,diarylheptanoid terpenes and diarylheptanoid-flavone hybrids are summarized.It provides references for their further development and utilization.

关 键 词：山姜属 二苯基庚烷 化学成分 生物活性 药理作用 研究进展 

分 类 号：R284.1[医药卫生—中药学] R285.5[医药卫生—中医学]