针药并用治疗宫颈单纯高危型HPV感染的临床研究  

Clinical study of acupuncture combined with medication in treating cervical simple high-risk HPV infection

作　　者：兰晓玉[1] 王辉 史崑 孙小红[1] 王陶然[1] LAN Xiaoyu;WANG Hui;SHI Kun;SUN Xiaohong;WANG Taoran(Beijing Geriatric Hospital,Beijing 100095,China;Beijing Xiaotangshan Hospital,Beijing 102211,China)

机构地区：[1]北京老年医院,北京100095 [2]北京小汤山医院,北京102211

出　　处：《上海针灸杂志》2023年第11期1130-1134,共5页Shanghai Journal of Acupuncture and Moxibustion

基　　金：北京市医院管理局“青苗”计划(QML20182101)。

摘　　要：目的观察针药并用治疗宫颈单纯高危型人类乳头瘤病毒(human papillomavirus,HPV)感染的临床疗效及其对机体免疫功能的影响。方法将120例宫颈单纯高危型HPV感染患者随机分为治疗组和对照组,每组60例。对照组采用外用重组人干扰素α-2b胶囊治疗,治疗组在对照组的基础上采用腹针治疗。观察两组治疗前后HPV DNA定量、免疫功能及匹兹堡睡眠质量指数(Pittsburgh sleep quality index,PSQI)评分变化,并比较两组HPV转阴率。结果两组治疗后HPV DNA定量低于治疗前,且治疗组低于对照组,差异有统计学意义(P<0.05)。治疗组治疗后CD3^(﹢)T细胞、CD4^(﹢)T细胞和CD8^(﹢)T细胞数量及CD4^(﹢)/CD8^(﹢)低于治疗前及对照组(P<0.05)。治疗组治疗后PSQI评分中睡眠质量、入睡时间、睡眠时间、睡眠障碍、睡眠效率、日间功能评分及总分低于治疗前和对照组(P<0.05)。治疗组HPV转阴率高于对照组(P<0.05)。结论针药并用可以改善宫颈单纯高危型HPV感染患者的机体免疫力,降低HPV DNA的数值,提高HPV转阴率,改善睡眠质量。Objective To observe the clinical efficacy of acupuncture plus medication in treating cervical simple high-risk human papillomavirus(HPV)infection and the effect on immune function.Method A total of 120 patients with cervical simple high-risk HPV infection were randomly divided into a treatment group and a control group,with 60 cases in each group.The control group was treated with the external use of recombinant human interferon α-2b capsules,and the treatment group was given additional abdominal acupuncture therapy.The post-treatment changes in HPV DNA load,immune function,and Pittsburgh sleep quality index(PSQI)score were observed,and the HPV clearance rate was compared between the two groups.Result The HPV DNA load decreased after the treatment in both groups and was lower in the treatment group than in the control group,showing statistical significance(P<0.05).The numbers of CD3^(﹢),CD4^(﹢),and CD8^(﹢)T cells and CD4^(﹢)/CD8^(﹢)dropped after the intervention in the treatment group and were lower than those in the control group(P<0.05).After the treatment,the PSQI component scores of sleep quality,sleep latency,sleep duration,sleep disturbances,sleep efficiency,and daytime function and the general score decreased in the treatment group and were lower than those in the control group(P<0.05).The treatment group had a higher HPV clearance rate than the control group(P<0.05).Conclusion Acupuncture plus medication can strengthen immunity,lower HPV DNA load,enhance HPV clearance rate,and improve sleep quality in patients with cervical simple high-risk HPV infection.

关 键 词：针药并用 腹针 人类乳头瘤病毒 免疫功能 匹兹堡睡眠质量指数 

分 类 号：R246.3[医药卫生—针灸推拿学]