妊娠期糖尿病胎儿认知功能障碍发病机制研究进展  

Research progress on the pathogenetic mechanism of fetal cognitive dysfunction caused by gestational diabetes

作　　者：戚天凤 陈涛 范易 邵志谦 周展鹏 高明洁[3] 杨婷婷 郝晶[3] 田飞[3] 王金环[3] QI Tianfeng;CHEN Tao;FAN Yi;SHAO Zhiqian;ZHOU Zhanpeng;GAO Mingjie;YANG Tingting;HAO Jing;TIAN Fei;WANG Jinhuan(The First School of Clinical Medicine,Heilongjiang University of Chinese Medicine;Graduate School,Heilongjiang University of Chinese Medicine;Department of Hematology,the First Hospital of Heilongjiang University of Chinese Medicine,Harbin,Heilongjiang 150040)

机构地区：[1]黑龙江中医药大学第一临床医学院,黑龙江哈尔滨150040 [2]黑龙江中医药大学研究生院 [3]黑龙江中医药大学附属第一医院血液病科,黑龙江哈尔滨150040

出　　处：《徐州医科大学学报》2023年第10期775-780,共6页Journal of Xuzhou Medical University

基　　金：国家自然科学基金(81673968);全国中医临床特色技术传承骨干人才项目(国中医药人教函〔2019〕36号);黑龙江省中医药学会青年中医药科技创新项目(ZHY19-029);黑龙江中医药大学创新人才基金(2018KCD04);黑龙江中医药大学科研基金项目(2019MS14)。

摘　　要：妊娠期糖尿病是一种常见的妊娠并发症,近年来发病率不断增高。妊娠期糖尿病会影响胎儿的神经系统发育,导致胎儿认知功能障碍,给社会带来了巨大的经济负担。然而,目前有关妊娠期糖尿病导致的胎儿认知功能障碍的具体机制尚未阐明。本文就二十二碳六烯酸(DHA)胎盘转移受阻、小胶质细胞促炎反应、铁元素缺乏和IL-1β增加引起胰岛素抵抗等4种机制展开综述,对妊娠期糖尿病导致的胎儿认知功能障碍的机制进行进一步探讨,为治疗提供更多的研究靶点。Gestational diabetes is a common complication of pregnancy,with an increasing incidence in recent years.Gestational diabetes affects the neurological development of the fetus and leads to fetal cognitive dysfunction,which imposes a huge economic burden on the society.However,the specific mechanisms by which gestational diabetes causes fetal cognitive dysfunction have not been elucidated yet.In this paper,we review four mechanisms,including impaired placental transfer of DHA,pro-inflammatory response of microglia,iron deficiency and insulin resistance caused by increased IL-1β,and further explore the mechanisms of fetal cognitive dysfunction caused by gestational diabetes,in order to provide more research targets for treatment.

关 键 词：妊娠期糖尿病 胎儿 认知功能障碍 机制 治疗 

分 类 号：R714.256[医药卫生—妇产科学]