骨关节炎治疗用水凝胶研究进展  

Recent advances in hydrogel for osteoarthritis treatment

作　　者：焦涵 吴承伟[1] 迟海涛[2] 张伟[1] JIAO Han;WU Chengwei;CHI Haitao;ZHANG Wei(State Key Laboratory of Structure Analysis for Industrial Equipment,Biomechanics and Nanomechanics Laboratory in Department of Engineering Mechanics,Dalian University of Technology,Dalian 116024,China;Department of Neurology,Xinhua Hospital Affiliated to Dalian University,Dalian 116021,China)

机构地区：[1]大连理工大学工程力学系生物与纳米力学实验室,工业装备结构分析国家重点实验室,大连116024 [2]大连大学附属新华医院神经内科,大连116021

出　　处：《科技导报》2023年第18期72-83,共12页Science & Technology Review

基　　金：国家重点研发计划项目(2022YFE0115400,2018YFA0704103,2018YFA0704104);教育部“春晖计划”合作科研项目(HZKY20220413);中央高校基本科研业务费项目(DUT21TD105,DUT22YG123)。

摘　　要：骨关节炎(OA)是易发于中老年群体的一种退行性病变,侵蚀关节软骨及其附属组织,严重影响患者的生活。水凝胶生物相容性好、力学性能优良,由其制成的功能性水凝胶可以弥补目前OA常用疗法中药物作用时间短、难以实现软骨组织再生等缺点,受到广泛的关注。总结了水凝胶在OA药物治疗、软骨缺损修复、关节滑液修复等方面的研究进展,探讨了药物释放水凝胶消炎止疼原理和药物缓释机理、软骨缺损修复水凝胶的修复机理以及关节润滑水凝胶的润滑机制。探讨了水凝胶治疗OA中存在的问题及其发展方向。Osteoarthritis(OA)is a degenerative disease that is prone to occur in the middle-aged and elderly groups.It can erode articular cartilage and its affiliated organization,and seriously affect the life of patients.Hydrogels have good biocompatibility and excellent mechanical properties.Functional hydrogels can make up for the shortcomings of short drug action time and the difficulties to cure OA in common therapy approaches.In this article,we review the recent advances of hydrogel as a carrier to treat osteoarthritis from the aspects of drug treatment of osteoarthritis,cartilage defect repair,and synovial fluid repair.The anti-inflammatory and analgesic mechanism of drug release hydrogel,the mechanism of cartilage repair of cartilage defect repair hydrogel and the joint lubrication mechanism of joint lubrication hydrogel were discussed.On these bases,we also summarize the existing problems and propose further development direction of hydrogel in the treatment of OA.

关 键 词：骨关节炎 水凝胶 药物治疗 软骨缺损修复 关节滑液修复 

分 类 号：R684.3[医药卫生—骨科学]