寻常型银屑病与血脂异常的相关性研究  

Correlations between psoriasis vulgaris and dyslipidemia

作　　者：阮诗钒 张鹏 林婷婷[1] 罗仁炜 鲍思怡 薛晨瑶 童泽群 张亮亮 龚婷 纪超[1,2] Ruan Shifan;Zhang Peng;Lin Tingting;Luo Renwei;Bao Siyi;Xue Chenyao;Tong Zequn;Zhang Liangliang;Gong Ting;Ji Chao(Department of Dermatology,The First Affiliated Hospital of Fujian Medical University,The Key Laboratory of Skin Cancer of Fujian Higher Education Institutions,Fuzhou 350000,China;National Clinical Research Center for Dermatologic and Immunologic Diseases,Fuzhou 350000,China;Central Laboratory,The First Affiliated Hospital of Fujian Medical University,Fuzhou 350000,China)

机构地区：[1]福建医科大学附属第一医院皮肤科、皮肤肿瘤福建省高等学校重点实验室,福州350000 [2]国家皮肤与免疫疾病临床医学研究中心,福州350000 [3]福建医科大学附属第一医院中心实验室,福州350000

出　　处：《中华皮肤科杂志》2023年第11期1043-1046,共4页Chinese Journal of Dermatology

摘　　要：目的探究福建地区寻常型银屑病(PsV)患者血脂水平与临床特征的相关性。方法纳入2019年3月至2022年3月就诊于福建医科大学附属第一医院皮肤科的245例PsV患者,以250例性别、年龄、身体质量指数(BMI)相匹配的健康体检者作为对照组,检测血脂、肝功能、肾功能等相关生化指标。记录PsV患者的病程、累及特殊部位、吸烟饮酒史、家族史等临床资料,分析临床资料与血脂异常之间的相关性。计量资料采用t检验或Mann-Whitney U检验分析组间差异,计数资料比较采用χ^(2)检验。结果PsV组122例(50.8%)伴血脂异常,对照组94例(37.6%)伴血脂异常,两组差异有统计学意义(χ^(2)=7.48,P=0.006),PsV组低高密度脂蛋白胆固醇血症率(29.8%)高于对照组(18.8%,χ^(2)=8.15,P=0.004)。PsV组血清总胆固醇、高密度脂蛋白胆固醇、载脂蛋白A1水平[4.5(3.9,5.2)mmol/L、1.1(1.0,1.3)mmol/L、1.2(1.1,1.4)g/L]均低于对照组[4.9(4.3,5.4)mmol/L、1.3(1.1,1.5)mmol/L、1.3(1.2,1.5)g/L,均P<0.001]。伴血脂异常PsV组男性、有饮酒史、掌跖部位受累比例(92.6%、13.1%、13.8%)高于不伴血脂异常PsV组(70.7%、6.0%、5.0%,均P<0.05)。多因素Logistic回归分析结果显示,男性、BMI≥25 kg/m^(2)的PsV患者患血脂异常的风险更高[OR值(95%CI)分别为3.94(1.74,9.74)、3.18(1.71,6.09)],掌跖部位受累可增加合并高脂血症的独立风险[OR值(95%CI)为3.38(1.18,11.01)]。结论PsV患者血脂异常率高于正常人群,男性、BMI≥25 kg/m^(2)和掌跖部位受累的PsV患者更容易发生脂代谢紊乱。Objective To investigate correlations between blood lipid levels and clinical characteristics of patients with psoriasis vulgaris(PsV)in Fujian province.Methods Totally,245 PsV patients were enrolled from Department of Dermatology of the First Affiliated Hospital of Fujian Medical University from March 2019 to March 2022,and 250 gender-,age-,and body mass index-matched health checkup examinees served as controls.Their biochemical indicators,such as blood lipids,liver function,and kidney function,were evaluated.Clinical data,such as disease courses,involvement of specific sites,history of smoking and alcohol consumption,and family history of psoriasis,were collected from the PsV patients,and correlations between these clinical data and dyslipidemia were analyzed.Measurement data were compared using t test or Mann-Whitney U test,and enumeration data were compared using chi-square test.Results There were 122(50.8%)patients with dyslipidemia in the PsV group and 94(37.6%)in the control group,and the prevalence of dyslipidemia significantly differed between the two groups(χ^(2)=7.48,P=0.006).The prevalence of hypo-high-density lipoprotein cholesterolemia was significantly higher in the PsV group(29.8%)than in the control group(18.8%;χ^(2)=8.15,P=0.004).The PsV group showed significantly decreased serum levels of total cholesterol(4.5[3.9,5.2]mmol/L),high-density-lipoprotein cholesterol(1.1[1.0,1.3]mmol/L),and apolipoprotein A1(1.2[1.1,1.4]g/L)compared with the control group(4.9[4.3,5.4]mmol/L,1.3[1.1,1.5]mmol/L,1.3[1.2,1.5]g/L,respectively;all P<0.001).The proportions of males,patients with a history of alcohol consumption,and patients with involvement of the palmoplantar sites were significantly higher in the PsV patients with dyslipidemia(92.6%,13.1%,13.8%,respectively)than in those without dyslipidemia(70.7%,6.0%,5.0%,respectively;all P<0.001).Multifactorial logistic regression analysis showed that"male"and"BMI≥25 kg/m^(2)"were independent risk factors for dyslipidemia in the PsV patients(OR[95%CI]:3.94[1.74,9.

关 键 词：银屑病 血脂异常 人体质量指数 胆固醇 危险因素 

分 类 号：R758.63[医药卫生—皮肤病学与性病学] R589.2[医药卫生—临床医学]