儿童黑素瘤临床研究进展  

Clinical progress in pediatric melanoma

作　　者：曹蒙 洪安澜 王焱 方方 Cao Meng;Hong Anlan;Wang Yan;Fang Fang(Department of Dermatologic Surgery,Hospital of Dermatology,Chinese Academy of Medical Sciences and Peking Union Medical College,Nanjing 210042,China)

机构地区：[1]中国医学科学院、北京协和医学院皮肤病医院皮肤外科,南京210042

出　　处：《中华皮肤科杂志》2023年第11期1074-1078,共5页Chinese Journal of Dermatology

基　　金：国家自然科学基金(81872216)。

摘　　要：儿童黑素瘤较为罕见,不同亚型的肿瘤存在发病机制的差异。部分肿瘤临床表现并不典型,成人黑素瘤诊断标准可能不完全适用于儿童。手术是一线治疗手段,具体切缘范围可小于成人。近年来黑素瘤的免疫治疗、靶向治疗等治疗手段迅速发展,但相关药物很少获批儿童适应证。儿童黑素瘤治疗的大样本研究也较少,但有文献报道相关药物的应用。本文综述儿童黑素瘤发病机制、临床表现和治疗的相关进展,以期为儿童黑素瘤的诊治提供参考。Pediatric melanoma occurs rarely,and the pathogenesis is different in different subtypes.The diagnostic criteria for adult melanoma may not be fully applicable to pediatric patients due to atypical clinical manifestations of some tumors.Surgery is the first?line treatment,and the accurate resection margin could be smaller than that in adults.In recent years,immunotherapy and targeted therapy for melanoma have developed rapidly,but very few drugs have been approved for children.Although there have been few large?sample studies on the treatment of pediatric melanoma,the application of related drugs has been reported in literature.This review summarizes progress in the pathogenesis,clinical manifestations and treatment of pediatric melanoma,in order to provide a reference for the diagnosis and treatment of pediatric melanoma.

关 键 词：儿童 痣和黑素瘤 分子靶向治疗 Spitz痣样黑素瘤 免疫检查点抑制剂 

分 类 号：R739.5[医药卫生—肿瘤]