基于VAP+血脂分型检测的肥胖孕妇血脂亚组分与新生儿不良出生结局的相关性研究  

Study on the correlations between blood lipid subcomponents of obese pregnant women and adverse birth outcomes based on VAP+ blood lipid typing

作　　者：毛郁蕾 潘聪桃 苏芳芳 陈舒影 冯泽蛟 李喜梅 MAO Yu-lei;PAN Cong-tao;SU Fang-fang;CHEN Shu-ying;FENG Ze-jiao;LI Xi-mei(Department of Gynecology and Obstetrics,Wenzhou Central Hospital,Zhejiang 325000,China;不详)

机构地区：[1]温州市中心医院妇产科,浙江温州325000 [2]温州医科大学附属第一医院检验科

出　　处：《中国妇幼保健》2023年第21期4153-4156,共4页Maternal and Child Health Care of China

基　　金：浙江省温州市科学技术局基础性科研项目(Y20210362)。

摘　　要：目的 研究基于VAP+血脂分型检测的肥胖孕妇血脂亚组分与新生儿不良出生结局的相关性。方法 选取2021年1—10月在温州市中心医院进行产前检查的136例肥胖孕妇作为研究组,同期进行产前检查的健康孕妇150例作为对照组。通过试剂盒直接测定法检测两组孕妇血清高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)水平,采用GPO-PAP法检测血清三酰甘油(TG)、总胆固醇(TC)水平,采用VAP+血脂分型技术检测血清脂蛋白(a)[LP(a)]、残粒脂蛋白胆固醇(RLP-C)、载脂蛋白A(ApoA)、载脂蛋白B(ApoB)水平。采用Pearson法分析肥胖孕妇血脂水平与新生儿不良出生结局的相关性。结果 对照组HDL-C、LDL-C、TG、TC、LP(a)、RLP-C、ApoA、ApoB水平分别为(3.74±0.46)mmol/L、(2.39±0.52)mmol/L、(3.08±0.41)mmol/L、(4.36±0.80)mmol/L、(139.15±11.84)mg/L、(0.18±0.14)mmol/L、(1.90±0.37)g/L、(0.79±0.12)g/L;研究组HDL-C、LDL-C、TG、TC、LP(a)、RLP-C、ApoA、ApoB水平分别为(2.96±0.35)mmol/L、(3.72±0.49)mmol/L、(4.10±0.39)mmol/L、(6.79±0.62)mmol/L、(220.83±50.61)mg/L、(0.30±0.16)mmol/L、(2.20±0.45)g/L、(0.96±0.20)g/L。研究组孕妇的血清LDL-C、TG、TC、LP(a)、RLP-C、ApoA、ApoB水平均高于对照组,HDL-C水平低于对照组,差异均有统计学意义(均P<0.05)。研究组早产儿、巨大儿、高胆红素血症发生率均高于对照组,差异均有统计学意义(均P<0.05)。Pearson相关性分析发现:肥胖孕妇的血清HDL-C、LDL-C、TG、TC、LP(a)、RLP-C、ApoA、ApoB水平与早产儿、新生儿窒息、巨大儿、高胆红素血症及低出生体质量儿发生率均呈正相关(均P<0.05)。结论 肥胖孕妇的血脂水平明显增高,且和新生儿不良出生结局存在相关性,临床需强化孕期血脂监测,并给予针对性预防干预措施。Objective To study the correlations between blood lipid subcomponents of obese pregnant women and adverse birth outcomes based on VAP+ blood lipid typing.Methods A total of 136 cases of obese pregnant women in Wenzhou Central Hospital from January to October 2022 were selected as research group,150 cases of healthy pregnant women receiving prenatal examination during the same period were selected as control group.The levels of serum high-density lipoprotein cholesterol(HDL-C) and low-density lipoprotein cholesterol(LDL-C) in the two groups were detected by kit direct assay method.The levels of serum triacylglycerol(TG) and total cholesterol(TC) were detected by GPO-PAP method.VAP+ blood lipid subcomponent classification was used to detect serum lipoprotein(a) [LP(a)],remnant lipoprotein cholesterol(RLP-C),apolipoprotein A(ApoA),and apolipoprotein B(ApoB) levels.Pearson method was used to analyze the correlations between blood lipid levels of obese pregnant women and adverse birth outcomes.Results The levels of serum HDL-C,LDL-C,TG,TC,LP(a),RLP-C,ApoA,and ApoB in study group were(3.74±0.46)mmol/L,(2.39±0.52)mmol/L,(3.08±0.41)mmol/L,(4.36±0.80)mmol/L,(139.15±11.84)mg/L,(0.18±0.14)mmol/L,(1.90±0.37)g/L,and(0.79±0.12)g/L,respectively.The levels of serum HDL-C,LDL-C,TG,TC,LP(a),RLP-C,ApoA,and ApoB in control group were(2.96±0.35)mmol/L,(3.72±0.49)mmol/L,(4.10±0.39)mmol/L,(6.79±0.62)mmol/L,(220.83±50.61)mg/L,(0.30±0.16)mmol/L,(2.20±0.45)g/L,and(0.96±0.20)g/L,respectively.The levels of serum LDL-C,TG,TC,LP(a),RLP-C,ApoA,and ApoB in study group were significantly higher than those in control group,the level of HDL-C in study group was statistically significantly lower than that in control group(P<0.05).The incidence rates of premature infant,macrosomia,and hyperbilirubinemia in study group were statistically significantly higher than those in control group(P<0.05).Pearson correlation analysis showed that serum HDL-C,LDL-C,TG,TC,LP(a),RLP-C,ApoA,and ApoB levels in obese pregnant women were positively corre

关 键 词：VAP+血脂分型检测 妊娠期肥胖 血脂 新生儿 妊娠结局 相关性 

分 类 号：R714.2[医药卫生—妇产科学]