日本乙型脑炎病毒蛋白与宿主蛋白相互作用的研究进展  

Progress in study of interaction between Japanese encephalitis virus proteins and host proteins

作　　者：袁盛林 汤德元[1] 陈阊峥 罗柳 陈旭 廖正波 YUAN Shenglin;TANG Deyuan;CHEN Changzheng;LUO Liu;CHEN Xu;LIAO Zhengbo(College of Animal Science,Guizhou University,Guiyang 550025,China)

机构地区：[1]贵州大学动物科学学院,贵州贵阳550025

出　　处：《中国兽医学报》2023年第8期1765-1770,共6页Chinese Journal of Veterinary Science

基　　金：国家自然科学基金资助项目(31860716)。

摘　　要：日本脑炎病毒(JEV)是世界上最常见的蚊媒病毒性脑炎病毒,严重危害养殖业以及人类健康,并且没有特异性疗法。迄今为止,日本脑炎(JE)只能通过疫苗预防,但是疫苗的预防也有一定的局限性。JEV主要编码3种结构蛋白和7种非结构蛋白,在病毒感染宿主过程中,病毒的结构蛋白和非结构蛋白与宿主蛋白相互作用。JEV的侵入、复制和致病性等与这些蛋白密切相关,因此可以从蛋白设计相应治疗JEV引起脑炎的方案。本文将JEV相关蛋白与宿主蛋白相互作用的机制进行综述,以期为今后JE的预防和治疗提供参考。Japanese encephalitis virus(JEV)is the most common mosquito-borne viral encephalitis virus in the world,posing a serious risk to farming as well as human health,and has no specific therapy.JEV encodes three structural and seven non-structural proteins,which interact with host proteins during the process of virus infection.In this paper,the JEV-associated proteins are linked to the host proteins.In this paper,we review the mechanisms of interaction between JEV-related proteins and host proteins in order to provide a reference for future Japanese encephalitis(JE)prevention and treatment.

关 键 词：日本乙型脑炎病毒(JEV) 结构蛋白 非结构蛋白 宿主蛋白 蛋白相互作用 

分 类 号：S852.65[农业科学—基础兽医学]