Chronic Kidney Disease Induces Cognitive Impairment in the Early Stage  

作　　者：Yu WANG Kai CHEN Zi-xuan QIAO Xiao-rong BAO 

机构地区：[1]Department of Nephrology,Jinshan Hospital,Fudan University,Shanghai 201508,China

出　　处：《Current Medical Science》2023年第5期988-997,共10页当代医学科学（英文）

基　　金：the Youth Fund of the Shanghai Municipal Health Commission(No.20164Y0266).

摘　　要：Objective Previous research indicates a link between cognitive impairment and chronic kidney disease(CKD),but the underlying factors are not fully understood.This study aimed to investigate the progression of CKD-induced cognitive impairment and the involvement of cognition-related proteins by developing early-and late-stage CKD models in Sprague-Dawley rats.Methods The Morris water maze test and the step-down passive avoidance task were performed to evaluate the cognitive abilities of the rats at 24 weeks after surgery.Histopathologic examinations were conducted to examine renal and hippocampal damage.Real-time PCR,Western blotting analysis,and immunohistochemical staining were carried out to determine the hippocampal expression of brain-derived neurotrophic factor(BDNF),choline acetyltransferase(ChAT),and synaptophysin(SYP).Results Compared with the control rats,the rats with early-stage CKD exhibited mild renal damage,while those with late-stage CKD showed significantly increased serum creatinine levels as well as apparent renal and brain damage.The rats with early-stage CKD also demonstrated significantly impaired learning abilities and memory compared with the control rats,with further deterioration observed in the rats with late-stage CKD.Additionally,we observed a significant downregulation of cognition-related proteins in the hippocampus of rats with early-stage CKD,which was further exacerbated with declining renal function as well as worsening brain and renal damage in rats with late-stage CKD.Conclusion These results suggest the importance of early screening to identify CKD-induced cognitive dysfunction promptly.In addition,the downregulation of cognition-related proteins may play a role in the progression of cognitive dysfunction.

关 键 词：chronic kidney disease cognitive impairment Morris water maze test brain-derived neurotrophic factor choline acetyltransferase SYNAPTOPHYSIN 

分 类 号：R692[医药卫生—泌尿科学]