Effect of Sr^(2+)on 3D gel-printed Sr_(3-x)Mg_(x)(PO_(4))_(2)composite scaffolds for bone tissue engineering  

作　　者：Hongyuan Liu Jialei Wu Siqi Wang Jing Duan Huiping Shao 

机构地区：[1]Institute for Advanced Materials and Technology,University of Science and Technology Beijing,Beijing 100083,China

出　　处：《International Journal of Minerals,Metallurgy and Materials》2023年第11期2236-2244,共9页矿物冶金与材料学报（英文版）

基　　金：financially supported by the Key Research and Development Projects of the People’s Liberation Army,China(No.BWS17J036)。

摘　　要：Porous magnesium strontium phosphate(Sr_(3-x)Mg_(x)(PO_(4))_(2))(x=2,2.5,3)composite scaffolds were successfully prepared by three dimension gel-printing(3DGP)method in this study.The results show that Sr_(0.5)Mg_(2.5)(PO_(4))_(2)scaffolds had good compressive strength,and Sr_(1.0)Mg_(2.0)(PO_(4))_(2)scaffolds had good degradation rate in vitro.The weight loss rate of Sr_(1.0)Mg_(2.0)(PO_(4))_(2)scaffolds soaked in simulated body fluid(SBF)or 6 weeks was 6.96%,and pH value varied between 7.50 and 8.61,which was within the acceptable range of human body.Preliminary biological experiment shows that MC3T3-E1 cells had good adhesion and proliferation on the surface of Sr_(3-x)Mg_(x)(PO_(4))_(2)scaffolds.Compared with pure Mg3(PO_(4))_(2)scaffolds,strontium doped scaffolds had excellent comprehensive properties,which explain that Sr_(3-x)Mg_(x)(PO_(4))_(2)composite scaffolds can be used for bone tissue engineering.

关 键 词：3D printing magnesium phosphatase STRONTIUM porous scaffolds DEGRADABILITY 

分 类 号：R318.08[医药卫生—生物医学工程]