Monodispersed covalent organic framework nanocrystals in aqueous solution for DNA inclusion  

作　　者：Xinheng Lyu Lezhi Yi Liang Zhang Jin Liu Hexiang Deng 

机构地区：[1]Key Laboratory of Biomedical Polymers-Ministry of Education,College of Chemistry and Molecular Sciences,Wuhan University,Wuhan 430072,China [2]Hubei Yangtze Memory Laboratories,Wuhan 430205,China [3]Department of Chemistry,The Hong Kong Branch of Chinese National Engineering Research Center for Tissue Resto-ration and Reconstruction,The Hong Kong University of Science and Technology,Hong Kong 999077,China

出　　处：《Science China Chemistry》2023年第11期3161-3168,共8页中国科学（化学英文版）

基　　金：supported by the National Natural Science Foundation of China(NSFC)(22025106 and 21971199);the National Key Research and Development Program of China(2022YFA1502902)。

摘　　要：Covalent organic framework(COF)nanocrystals are useful in biological applications;however,their hydrophobic nature makes them aggregate into clusters in aqueous media.In this work,we show that by modifying the crystal surface with hydrophilic functional groups,these nanocrystals can maintain in the monodispersed form in aqueous solution.Specifically,three COFs,TPB-DMTP COF,TAPB-PDA COF and TAPB-BPDA COF were synthesized using organic Lewis acid as the catalyst,to generate nanoparticles with the size ranging from 180 nm to 1μm.2-Aminoethanesulfonic acid(AESA)was applied to react with the terminal aldehyde functional groups exposed at the surface of COF nanocrystals.The resulting negatively charged surface keeps these nanocrystals apart from each other in aqueous solution for at least 48 h.The mesopore of these COF nanocrystals allows the entering of single-strand DNA molecules and the release in the presence of complementary DNA.

关 键 词：covalent organic framework nanocrystals in aqueous solution DNA inclusion 

分 类 号：TB383.1[一般工业技术—材料科学与工程]