Engineering advanced dynamic biomaterials to optimize adoptive T-cell immunotherapy  被引量:1

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作  者:Wai Ki Wong Bohan Yin Anel Rakhmatullina Jingying Zhou Siu Hong Dexter Wong 

机构地区:[1]Department of Bioengineering,Imperial College London,London SW72AZ,United Kingdom [2]Department of Biomedical Engineering,The Hong Kong Polytechnic University,Kowloon,Hong Kong,China [3]School of Biomedical Sciences,The Chinese University of Hong Kong,Shatin,Hong Kong,China

出  处:《Engineered Regeneration》2021年第1期70-81,共12页再生工程(英文)

基  金:the start-up funding(A0033912)from the Department of Biomedical Engineering;Start-up Fund for RAPs under the Strategic Hiring Scheme(0035876);the Hong Kong Polytechnic University(University Grant Council),for supporting this work.

摘  要:Adoptive T-cell therapy(ACT)is a promising therapeutic approach based on the concept of potent T-cell mediated immunity against the tumor.The outcome of antigen-specific T-cells responses relies on the interaction between T-cells and antigen-presenting cells,which provides signals for generating different T-cell phenotypes with different roles in tumor removal.However,such interaction is often not optimal in vivo and results in low therapeutic efficacy.To reach the full potential of the T-cell response,current research put effort into developing dynamic biomaterials as artificial antigen-presenting cells to study and regulate the T-cell activity for controlling T-cell fate.In this perspective,we provide(1)an overview of ACT and general T-cells behaviors,(2)explore the insight on how biomaterials can be used for studying and regulating T-cell behaviors,(3)and discuss conceptual gaps in knowledge for biomaterials-based immunotherapy.

关 键 词:T-cell mechanobiology Dynamic nanobiomaterials Adoptive T-cell immunotherapy T-Ligand presentation 

分 类 号:R31[医药卫生—基础医学]

 

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