SIRT1基因突变致感音神经性聋的研究及其与年龄的相关性  

A Study on the Association between Sirt1 Gene Polymorphism and Age in Sensorineural Hearing Loss

作　　者：梁佳[1] 吴琼芳[1] 马宁 张社江[1] LIANG Jia;WU Qiong-fang;MA Ning;ZHANG She-jiang

机构地区：[1]邯郸市第三医院耳鼻喉科,邯郸056001

出　　处：《中国听力语言康复科学杂志》2023年第6期601-606,共6页Chinese Scientific Journal of Hearing and Speech Rehabilitation

基　　金：邯郸市科学技术研究与发展计划项目“经迷路及面隐窝入路透明面神经、鼓索神经人工耳蜗植入术治疗合并共同腔畸形及伴分泌性中耳炎的重度感音神经性聋患者效果研究”(21422083104)。

摘　　要：目的 探讨不同年龄段人群沉默信息调节因子相关酶1(silent mating type information regulator 1,SIRT1)基因多态性与感音神经性聋的相关性。方法 以2021年3月~2022年12月我院就诊的105例感音神经性聋患者为观察组,同期在我院体检的同龄105例健康人群为对照组。根据年龄将观察组分为A组(<60岁)和B组(≥60岁),对照组分为C组(<60岁)和D组(≥60岁)。对所有患者进行DNA提取和SIRT1 rs7895833、rs7069102、rs2273773三个位点的基因多态性检测,分析其与感音神经性聋的相关性。结果 (1)观察组和对照组rs2273773、rs7069102基因型/等位基因分布差异无统计学意义(P>0.05)。(2)4个亚组rs2273773、rs7069102基因型/等位基因分布差异无统计学意义(P>0.05)。(3)观察组和对照组rs7895833基因型/等位基因分布差异具有统计学意义,观察组rs7895833 GG型显著高于对照组(P<0.05)。(4)A组和C组rs7895833基因型/等位基因分布差异无统计学意义(P>0.05);B组和D组rs7895833基因型/等位基因分布差异有统计学意义(P<0.05),B组GG型显著高于D组(P<0.05),等位基因G显著高于D组(P<0.05)。(5)Logistic回归分析显示,对于所有人群,GG型rs7895833基因型人群发生感音神经性聋的风险是AA型rs7895833基因型人群的1.919倍(95%CI:1.299~2.835,P<0.01);对于≥60岁人群,GG型rs7895833基因型人群发生感音神经性聋的风险是AA型rs7895833基因型人群的2.30倍(95%CI:1.409~3.755,P<0.01)。(6)感音神经性聋患者rs7895833基因型多态性GG型与年龄存在正相关(r=0.440,P<0.01)。结论 SIRT1基因GG基因型与感音神经性聋存在密切关系,是60岁以上老年人群发生感音神经性聋的危险因素。Objective To explore the correlation between polymorphism of silent matching type information regulator 1(SIRT1)gene and sensorineural hearing loss in different age groups.Methods 105 patients with sensorineural hearing loss who visited our hospital from March 2021 to December 2022 were selected as the observation group,while 105 healthy individuals of the same age who underwent physical examination at our hospital were selected as the control group.According to age,the observation group was further divided into Group A(<60 years old)and Group B(≥60 years old),while the control group was further divided into Group C(<60 years old)and Group D(≥60 years old).DNA extraction was performed on all patients,and gene polymorphisms at three loci:SIRT1 rs7895833,rs7069102,and rs2273773 were detected,and their correlation with sensorineural hearing loss was analyzed.Result(1)There was no statistically significant difference in the distribution of rs2273773 genotype/allele between the observation group and the control group(P>0.05);There was no statistically significant difference in the genotype/allele distribution of rs7069102 between the observation group and the control group(P>0.05).(2)There was no statistically significant difference in the distribution of rs2273773 genotype/allele and rs7069102 genotype/allele among the four subgroups(P>0.05).(3)There were statistically significant differences in the distribution of rs7895833 genotypes/alleles between the observation group and the control group.The rs7895833 GG genotype in the observation group was significantly higher than that in the control group(P<0.05).(4)There was no statistically significant difference in the genotype/allele distribution of rs7895833 between Group A and Group C(P>0.05);There was a statistically significant difference in the genotype/allele distribution of rs7895833 between Group B and Group D(P<0.05).The GG genotype in Group B was significantly higher than that in Group D(P<0.05),and the allele G was significantly higher than that in Group

关 键 词：沉默信息调节因子相关酶1 基因多态性 感音神经性聋 年龄 相关性 

分 类 号：R764.431[医药卫生—耳鼻咽喉科]