对症治疗、槐杞黄联合小剂量肝素预防过敏性紫癜性肾炎的效果  

Effect of Symptomatic Treatment and Huaiqihuang Combined with Low-dose Heparin on Prevention of Henoch Pur⁃pura Nephritis

作　　者：王青 张丽丽[1] 董改琴[1] Wang Qing;Zhang Lili;Dong Gaiqin(Department of Pediatrics,Affiliated Hospital of Yangzhou University,Yangzhou 225000,Jiangsu Province,China)

机构地区：[1]扬州大学附属医院儿科,江苏扬州225000

出　　处：《中外医药研究》2023年第20期78-80,共3页JOURNAL OF CHINESE AND FOREIGN MEDICINE AND PHARMACY RESEARCH

摘　　要：目的:探讨对症治疗、槐杞黄联合小剂量肝素预防过敏性紫癜性肾炎的临床效果。方法:选取2020年1月—2022年12月扬州大学附属医院儿科收治的过敏性紫癜患儿32例作为观察对象,随机分为观察组与对照组,各16例。对照组给予小剂量肝素治疗,观察组在对照组基础上给予槐杞黄治疗。比较两组临床治疗效果、免疫功能改善情况、肾功能指标改善情况及过敏性紫癜性肾炎发生情况。结果:观察组临床治疗总有效率高于对照组,差异有统计学意义(P=0.0325);治疗后,观察组免疫球蛋白A、免疫球蛋白G水平均低于对照组,差异有统计学意义(P<0.05);治疗后,观察组尿白蛋白、24 h尿蛋白定量水平均低于对照组,差异有统计学意义(P<0.05);观察组过敏性紫癜性肾炎发生率低于对照组,差异有统计学意义(P=0.033)。结论:在常规对症用药基础上引入槐杞黄联合小剂量肝素治疗过敏性紫癜患儿,可有效提升临床疗效,改善患儿的免疫功能、凝血功能与肾功能,预防过敏性紫癜性肾炎发生。Objective:To explore the clinical effect of symptomatic treatment and Huaiqihuang combined with low-dose heparin on prevention of henoch purpura nephritis.Methods:A total of 32 children with allergic purpura were selected as observation subjects in the Department of Pediatric,Affiliated Hospital of Yangzhou University from January 2020 to December 2022,and randomly divided into observation group and control group,with 16 cases in each group.The control group was treated with low-dose heparin,and the observation group was treated with Huaiqihuang on the basis of the control group.The clinical treatment effects,improvement of immune function,improvement of renal function indicators and occurrence of henoch purpura nephritis were compared between the two groups.Results:The total clinical treatment effectiveness of the observation group was higher than that of the control group,and the difference was statistically significant(P=0.0325);after treatment,the levels of immunoglobulin A and immunoglobulin G in the observation group were lower than those of the control group,and the difference was statistically significant(P<0.05);after treatment,the quantitative levels of urinary albumin and 24-hour urine protein in the observation group were lower than those in the control group,and the difference was statistically significant(P<0.05);the incidence of henoch purpura nephritis in the observation group was lower than that in the control group,the difference was statistically significant(P=0.033).Conclusion:On the basis of routine symptomatic medication,the introduction of Huaiqihuang combined with low-dose heparin in the treatment of children with anaphylactoid purpura can effectively improve the clinical efficacy,improve the immune function,coagulation function and renal function of children,and prevent the occurrence of anaphylactoid purpura nephritis.

关 键 词：槐杞黄 肝素 过敏性紫癜 肾炎 

分 类 号：R72[医药卫生—儿科]