多项生化指标联合检测在糖尿病肾病诊断中的应用价值  

Application Value of Multiple Biochemical Indexes Combined Detection in the Diagnosis of Diabetic Nephropathy

作　　者：潘叶萍 Pan Yeping(Department of Clinical Laboratory,Taiping Community Health Service Center,Xiangcheng District,Suzhou City,Suzhou 215100,Jiangsu Province,China)

机构地区：[1]苏州市相城区太平社区卫生服务中心检验科,江苏苏州215100

出　　处：《中外医药研究》2023年第20期141-143,共3页JOURNAL OF CHINESE AND FOREIGN MEDICINE AND PHARMACY RESEARCH

摘　　要：目的:研究多项生化指标联合检测在糖尿病肾病诊断中的应用价值。方法:选取2019年6月—2022年5月苏州市相城区太平社区卫生服务中心诊治的糖尿病肾病患者150例为糖尿病肾病组,并选取同期单纯糖尿病患者150例为单纯糖尿病组。两组患者均予以多项生化指标检测。比较两组患者生化指标,各检测方式诊断准确度,糖尿病肾病组不同严重程度生化指标。结果:糖尿病肾病组糖化血红蛋白(HbA_(1c))、尿肌酐比值(ACR)、同型半胱氨酸(Hcy)、胱抑素C(CysC)及视黄醇结合蛋白(RBP)水平均高于单纯糖尿病组,差异有统计学意义(P<0.001)。单项HbA_(1c)、单项ACR、单项Hcy、单项CysC及单项RBP检测诊断准确度低于联合检测,差异有统计学意义(P<0.001)。晚期糖尿病肾病患者HbA_(1c)、ACR、Hcy、CysC及RBP水平高于中期糖尿病肾病、晚期糖尿病肾病患者,中期糖尿病肾病患者HbA_(1c)、ACR、Hcy、CysC及RBP水平高于晚期糖尿病肾病患者,差异有统计学意义(P<0.001)。结论:为糖尿病肾病患者进行临床诊断时,通过多项生化指标进行联合检测能够进一步提高诊断的准确度,建议在实际的临床诊断中予以采用。Objective:To study the application value of multiple biochemical indexes combined detection in the diagnosis of diabetic nephropathy.Methods:A total of 150 patients with diabetic nephropathy diagnosed and treated in Taiping Community Health Service Center,Xiangcheng District,Suzhou City were selected as the diabetic nephropathy group from June 2019 to May 2022,and 150 patients with simple diabetes were selected as simple diabetes group during the same period.A number of biochemical indexes were detected in both groups.Biochemical indexes,diagnostic accuracy of each detection method and biochemical indexes of different severity in diabetic nephropathy group were compared between the two groups.Results:The levels of glycosylated hemoglobin(HbA_(1c)),urinary creatinine ratio(ACR),homocysteine(Hcy),cystatin C(CysC)and retinol-binding protein(RBP)in diabetic nephropathy group were higher than those in simple diabetic group,with statistical significance(P<0.001).The diagnostic accuracy of single HbA_(1c),single ACR,single Hcy,single CysC and single RBP was lower than that of the combined test,and the difference was statistically significant(P<0.001).The levels of HbA_(1c),ACR,Hcy,CysC and RBP in patients with advanced diabetic nephropathy were higher than those in patients with middle diabetic nephropathy and late-stage diabetic nephropathy,and the levels of HbA_(1c),ACR,Hcy,CysC and RBP in patients with mid-stage diabetic nephropathy were higher than those in patients with late-stage diabetic nephropathy,the difference was statistically significant(P<0.001).Conclusion:In the clinical diagnosis of diabetic nephropathy patients,the combined detection of multiple biochemical indicators can further improve the accuracy of diagnosis,and it is recommended to adopted in actual clinical diagnosis.

关 键 词：生化指标 联合检测 糖尿病肾病 准确度 

分 类 号：R58[医药卫生—内分泌]