基于时变频谱相干的工作记忆过程中海马-前额叶皮层局部场电位的同步特征模式研究  

Synchronized feature patterns of local field potentials in hippocampal-prefrontal cortex during working memory based on time-varying spectral coherence

作　　者：刘迢迢 王舒雅 孙金平 白文文 Liu Tiaotiao;Wang Shuya;Sun Jinping;Bai Wenwen(School of Biomedical Engineering and Technology,Tianjin Medical University,Tianjin 300070,China)

机构地区：[1]天津医科大学生物医学工程与技术学院,天津300070

出　　处：《国际生物医学工程杂志》2023年第4期281-287,共7页International Journal of Biomedical Engineering

基　　金：天津市教委科研计划项目(2020KJ209)。

摘　　要：目的基于时变频谱相干研究工作记忆过程中海马(HPC)和前额叶皮层(PFC)局部场电位的同步特征模式,为研究工作记忆的信息处理机制提供支持。方法采集6只SD大鼠在执行Y迷宫空间工作记忆任务过程中的腹侧海马(vHPC)和内侧前额叶皮层(mPFC)的局部场电位(LFPs)信号,应用短时傅里叶变换(STFT)计算vHPC和mPFC LFPs的时频分布,确定工作记忆的特征频段,进而基于时变频谱相干研究vHPC和mPFC LFPs特征频段的同步特征模式,最后应用支持向量机探索应用频谱相干值预测工作记忆的可行性。结果大鼠正确执行工作记忆时,HPC和PFC的theta频段(4~12 Hz)能量均增加(均P<0.01),且HPC-PFC theta频段的频谱相干值增加(P<0.05)。以正确和错误执行工作记忆时的平均频谱相干峰值和峰值与起始点的差值作为特征,进行支持向量机的训练和预测,准确率达89%,精确率达90%,召回率为88%,F1分数为88%,与随机打乱标签数据重排结果相比差异均有统计学意义(均P<0.05)。结论 HPC-PFC theta频段的同步协同是正确执行工作记忆时信息处理的潜在机制之一。Objective To investigate the synchronized feature patterns of local field potentials in the hippocampus(HPC)and prefrontal cortex(PFC)during working memory based on time-varying spectral coherence so as to support the study of information processing mechanisms in working memory.Methods The local field potentials(LFPs)signals of the ventral hippocampus(vHPC)and medial prefrontal cortex(mPFC)were collected from six SD rats during the performance of a spatial working memory task in the Y-maze,and the time-frequency distributions of vHPC and mPFC LFPs were calculated by applying the short-time Fourier transform(STFT)to determine the characteristic frequency bands of the working memory and then to investigate the synchronized patterns of vHPC and mPFC LFPs based on the coherent of the time-varying frequency spectrum.Finally,support vector machines were applied to explore the feasibility of applying spectral coherence values to predict working memory.Results When rats performed working memory tasks correctly,the energy of the theta band(4-12 Hz)of the HPC and PFC increased(all P<0.01),and the spectral coherence value of the theta band of the HPC-PFC increased(P<0.05).Support vector machine training and prediction using the average peak spectral coherence and the difference between the peak and the onset when correctly and incorrectly executing the working memory as features resulted in 89%accuracy,90%precision,88%recall,and 88%F1 scores,all of which were statistically significant differences compared to the results of the randomly disrupted labeled data rearranging(all P<0.05).Conclusions Synchronized synergy in the HPC-PFC theta band is one of the potential mechanisms for correctly performing information processing in working memory.

关 键 词：工作记忆 海马 前额叶皮层 局部场电位 时变频谱相干分析 

分 类 号：R338[医药卫生—人体生理学]