MHC-Ⅱ在病毒性感染中的作用研究进展  

Research progress on the role of MHC-Ⅱin viral infection

作　　者：周洁 吕忠霖 魏寅祥 韩根成 ZHOU Jie;LÜZhonglin;WEI Yinxiang;HAN Gencheng(National and Local Joint Engineering Laboratory of Antibody Drug Development Technology,School of Basic Medicine,Henan University,Kaifeng,Henan 475004,China;Institute of Military Cognition and Brain Sciences,Academy of Military Medical Sciences,Academy of Military Sciences,Beijing 100850,China;National Clinical Research Center for Geriatric Diseases,Department of Hematology,the Second Medical Center,Chinese PLA General Hospital,Beijing 100141,China)

机构地区：[1]河南大学基础医学院抗体药物开发技术国家地方联合工程实验室,河南开封475004 [2]军事科学院军事医学研究院军事认知与脑科学研究所,北京100850 [3]解放军总医院第二医学中心血液科,国家老年疾病临床研究中心,北京100141

出　　处：《军事医学》2023年第9期710-713,共4页Military Medical Sciences

基　　金：国家自然科学基金项目(81971473,82101913,82000211)。

摘　　要：病毒感染性疾病严重危害人们的生命健康,而近年暴发的新冠病毒感染给人们的身心健康和生产生活带来了严重影响。主要组织相容性复合物Ⅱ分子(MHC-Ⅱ)主要表达于B细胞、单核-巨噬细胞和树突状细胞等专职抗原递呈细胞上,参与调控体液免疫和细胞免疫应答。越来越多研究表明,MHC-Ⅱ在抗病毒感染及病毒免疫逃逸中发挥重要的生理及病理作用,但其机制仍不清楚,该文就MHC-Ⅱ在病毒性感染中的作用及研究进展进行了综述。Viral infectious diseases seriously endanger people′s life and health.The outbreak of coronavirus disease2019(COVID-19)infection in recent years has brought serious harm to people′s life,health,work and life.Major histocompatibility complexⅡ(MHC-Ⅱ)molecules are mainly expressed on professional antigen presenting cells such as B cells,mononuclear macrophages and dendritic cells,and participate in the regulation of humoral and cellular immune responses.More and more studies have shown that MHCⅡplays an important physiological and pathological role in antiviral infection and viral immune escape,but its mechanism is still unclear.This article reviews the research progress of MHC-Ⅱin viral infection.

关 键 词：病毒感染 主要组织相容性复合物Ⅱ 免疫逃逸 

分 类 号：R373[医药卫生—病原生物学]