云南省红河哈尼族彝族自治州心脑血管疾病患者血脂及载脂蛋白E基因情况分析  

Blood lipids and apolipoprotein E gene in patients with cardiovascular and cerebrovascular diseases in Honghe Hani and Yi Autonomous Prefecture of Yunnan Province

作　　者：童燕翔 林驰 汤进伟 陈晓鹏 Yanxiang Tong;Chi Lin;Jinwei Tang;Xiaopeng Chen(Department of Neurosurgery,Southern Central Hospital of Yunnan Province(The First People's Hospital of Honghe State),Mengzi 661199,Yunnan Province,China)

机构地区：[1]云南省滇南中心医院(红河哈尼族彝族自治州第一人民医院)神经外科,蒙自661199

出　　处：《中国基层医药》2023年第10期1467-1471,共5页Chinese Journal of Primary Medicine and Pharmacy

摘　　要：目的分析云南省红河哈尼族彝族自治州心脑血管疾病患者的血脂及载脂蛋白E(ApoE)基因分布情况,及其与民族、性别及年龄的关系。方法收集2019年5月至2020年6月云南省滇南中心医院(红河哈尼族彝族自治州第一人民医院)收治的心脑血管疾病患者102例为研究对象,分析其血脂及ApoE基因分布情况,并观察其与民族、性别及年龄的相关性。结果该地区心脑血管疾病患者的总胆固醇(TC)男女差异有统计学意义[(4.10±1.27)mmol/L比(4.70±1.83)mmol/L,t=1.87,P=0.048],TC值在不同民族及不同年龄段的差异均无统计学意义(P=0.343、1.000),低密度脂蛋白胆固醇(LDL-C)、高密度脂蛋白胆固醇(HDL-C)、三酰甘油(TG)在不同民族、不同性别及不同年龄的差异均无统计学意义(P=0.562、0.125、0.158;0.884、0.068、0.681;0.262、0.367、0.965)。血脂异常和血脂正常患者在不同民族、不同性别及不同年龄的差异均无统计学意义(P=0.890、0.336、0.142)。所有患者未检测到E2/E4基因,ApoE的E2/E2及E2/E3基因占16.67%,E3/E3占70.59%,E3/E4及E4/E4占12.74%,ApoE基因在不同民族、不同性别及不同年龄的差异均无统计学意义(χ^(2)=0.13、0.69、0.44,P=0.936、0.429、0.804)。结论云南省红河哈尼族彝族自治州心脑血管疾病女性患者TC水平高于男性患者,LDL-C、HDL-C及TG水平与民族、性别及年龄无明显关联,血脂异常以低HDL-C及高TG为主,E2/E4基因在该地区暂未发现。Objective To analyze the distribution of blood lipids and apolipoprotein E(ApoE)gene in patients with cardiovascular and cerebrovascular diseases in Honghe Hani and Yi Autonomous Prefecture of Yunnan Province,and their relationship with ethnicity,gender,and age.Methods A total of 102 patients with cardiovascular and cerebrovascular diseases who received treatment in Southern Central Hospital of Yunnan Province(The First People's Hospital of Honghe State)from May 2019 to June 2020 were included in this study.Their blood lipid and ApoE gene distributions were analyzed.The correlations between blood lipid and ApoE gene distribution and ethnicity,gender,and age were analyzed.Results There was a significant difference in total cholesterol level between male and female patients with cardiovascular and cerebrovascular diseases in Honghe Hani and Yi Autonomous Prefecture of Yunnan Province[(4.10±1.27)mmol/L vs.(4.70±1.83)mmol/L,t=1.87,P=0.048].There was no significant difference in total cholesterol level among different ethnic groups and different ages(P=0.343,1.000).There were no significant differences in low-density lipoprotein cholesterol,high-density lipoprotein cholesterol,and triglyceride levels among different ethnic groups,different sexes,and different ages(P=0.562,0.125,0.158;0.884,0.068,0.681;0.262,0.367,0.965).There were no significant differences in blood lipid levels among different ethnic groups,different sexes,and different ages(P=0.890,0.336,0.142).No E2/E4 gene was found in all patients.E2/E2 and E2/E3 genes of ApoE accounted for 16.67%,E3/E3 gene accounted for 70.59%,and E3/E4 and E4/E4 genes accounted for 12.74%.There was no significant difference in the distribution of ApoE gene among different ethnic groups,different sexes,and different ages(χ^(2)=0.13,0.69,0.44,P=0.936,0.429,0.804).Conclusion Female patients with cardiovascular and cerebrovascular diseases in Honghe Hani and Yi Autonomous Prefecture of Yunnan Province have higher total cholesterol levels than male patients.Low-density lipoprote

关 键 词：少数民族 血脂异常 载脂蛋白E类 基因表达 多态性 限制性片段长度 年龄因素 性别因素 

分 类 号：R54[医药卫生—心血管疾病]