大黄联合针刺治疗对重型颅脑损伤患者血浆IL-6及T、B淋巴细胞亚群的影响  

Effects of rhubarb combined with acupuncture treatment on plasma interleukin-6 level and T and B lymphocyte subsets in patients with severe traumatic brain injury

作　　者：荣风燕 王永林[2] 李金秀[1] Fengyan Rong;Yonglin Wang;Jinxiu Li(Department of Critical Care Medicine,The Second People's Hospital of Liaocheng(The Second Hospital of Liaocheng Affiliated to Shandong First Medical University),Liaocheng 252600,Shandong Province,China;Department of Clinical Pharmacy,The Second People's Hospital of Liaocheng(The Second Hospital of Liaocheng Affiliated to Shandong First Medical University),Liaocheng 252600,Shandong Province,China)

机构地区：[1]聊城市第二人民医院,山东第一医科大学附属聊城二院重症医学科,聊城252600 [2]聊城市第二人民医院,山东第一医科大学附属聊城二院临床药学科,聊城252600

出　　处：《中国基层医药》2023年第10期1477-1482,共6页Chinese Journal of Primary Medicine and Pharmacy

摘　　要：目的观察大黄联合针刺治疗对重型颅脑损伤(STBI)患者血浆白细胞介素6(IL-6)水平、T淋巴细胞亚群、B淋巴细胞亚群的影响。方法选取聊城市第二人民医院2020年9月至2022年8月收治的STBI患者112例为研究对象,采用随机对照研究方法,根据随机抽签法均分为对照组和观察组,每组56例。两组均给予常规治疗,对照组给予大黄治疗,观察组在对照组基础上辅以针刺治疗,观察比较两组患者的血浆T、B淋巴细胞亚群比值和IL-6水平变化及两组患者预后情况。结果治疗后,观察组总有效率[89.29%(50/56)]显著高于对照组[73.21%(41/56)](χ^(2)=4.75,P=0.029);两组治疗后第7 d的IL-6水平均显著低于治疗前(均P<0.05);观察组治疗后7 d的IL-6水平[(469.60±196.54)mg/L]显著低于对照组[(695.25±277.67)mg/L](t=4.96,P<0.05);观察组的T淋巴细胞亚群(CD_(4)^(+)、CD_(8)^(+)、CD_(4)^(+)/CD_(8)^(+))以及B淋巴细胞亚群(CD_(19)^(+)、CD_(20)^(+))比例均明显高于对照组,更接近正常值(均P<0.05);治疗后3个月,两组患者格拉斯哥预后量表(GOS)评分显著高于治疗后1个月的评分(均P<0.05);观察组患者治疗后1个月[(2.94±0.53)分]、3个月[(4.06±0.53)分]GOS评分均显著高于对照组[(2.63±0.58)分、(3.72±0.48)分](t=2.95、3.56,均P<0.05)。结论大黄联合针刺治疗能显著降低STBI患者血浆IL-6水平,调节T、B淋巴细胞亚群,降低炎性反应,改善患者的预后。Objective To investigate the effects of rhubarb combined with acupuncture treatment on plasma interleukin-6(IL-6)and T and B lymphocyte subsets in patients with severe traumatic brain injury.Methods A total of 112 patients with severe traumatic brain injury who received treatment in The Second People's Hospital of Liaocheng from September 2020 to August 2022 were included in this study.They were randomly divided into a control group and an observation group(n=56 per group).Both groups were given routine treatment.Additionally,the control group was treated with rhubarb,while the observation group was treated with rhubarb and acupuncture.The ratios of T lymphocyte subsets to B lymphocyte subsets,IL-6 levels,and prognoses were compared between the two groups.Results After treatment,the total effective rate in the observation group was 89.29%(50/56),which was significantly higher than 73.21%(41/56)in the control group(χ^(2)=4.75,P=0.029).At 7 days after treatment,IL-6 level in each group was significantly decreased compared with that before treatment(P<0.05).At 7 days after treatment,IL-6 level in the observation group was(469.60±196.54)mg/L,which was significantly lower than(695.25±277.67)mg/L in the control group(t=4.96,P<0.05).The ratios of T lymphocyte subsets(CD_(4)^(+),CD_(8)^(+),CD_(4)^(+)/CD_(8)^(+))to B lymphocyte subsets(CD_(19)^(+),CD_(20)^(+))in the observation group were significantly higher than those in the control group and were closer to the normal ratios(all P<0.05).At 3 months after treatment,the Glasgow Outcome Scale scores in each group were significantly increased compared with those at 1 month after treatment(both P<0.05).At 1 and 3 months after treatment,the Glasgow Outcome Scale scores in the observation group were(2.94±0.53)points and(4.06±0.53)points,respectively,which were significantly higher than(2.63±0.58)points and(3.72±0.48)points in the control group(t=2.95,3.56,both P<0.05).Conclusion Rhubarb combined with acupuncture can greatly reduce serum IL-6 level in patients with sever

关 键 词：颅脑损伤 针刺穴位 大黄 T淋巴细胞 B淋巴细胞 白细胞介素6 格拉斯哥预后评分 治疗结果 预后 

分 类 号：R269[医药卫生—中西医结合]