孕早期超声检测子宫动脉血流参数与妊娠结局的相关性研究  

Correlation between uterine artery blood flow parameters detected by ultrasound examination during early pregnancy and pregnancy outcomes

作　　者：边焕杰 陈阳 Huanjie Bian;Yang Chen(Department of Ultrasonography,Zhuji Maternal and Child Health Hospital,Shaoxing 311800,Zhejiang Province,China)

机构地区：[1]诸暨市妇幼保健院超声科,诸暨311800

出　　处：《中国基层医药》2023年第10期1545-1549,共5页Chinese Journal of Primary Medicine and Pharmacy

摘　　要：目的探讨有复发性流产史孕妇孕早期超声检测子宫动脉血流参数与妊娠结局的关系。方法选择诸暨市妇幼保健院2020年6月至2022年6月收治的孕6~10周的有复发性流产史孕妇100例为研究组;采用病例对照研究方法,另选择在该院同期体检的孕6~10周的正常孕妇100例作为对照组。两组孕妇均采用彩色多普勒超声诊断仪检测子宫动脉血流参数[子宫动脉收缩期峰值流速/舒张期流速(S/D)、阻力指数(RI)和搏动指数(PI)]。观察两组早期流产发生情况;分析子宫动脉血流参数对不良妊娠结局的预测价值及相关性;采用多因素logistic回归分析子宫动脉血流参数与不良妊娠结局的关系。结果研究组S/D(3.87±0.43)、RI(0.93±0.16)和PI(1.73±0.41),均高于对照组的(2.54±0.37)、(0.64±0.14)和(1.24±0.35)(t=23.44、13.64、9.09,均P<0.001)。研究组早期流产率[57.0%(57/100)]高于对照组[2.0%(2/100)](χ^(2)=72.73,P<0.05)。经受试者工作特征曲线分析显示,不良妊娠结局预测价值,S/D灵敏度为79.1%,特异度为70.2%;RI灵敏度为88.4%,特异度为84.2%;PI灵敏度为65.1%,特异度为75.4%。经Pearson分析显示,S/D、RI和PI与不良妊娠结局发生呈线性正相关(r=0.587、0.648、0.613,均P<0.001)。结论复发性流产史孕妇孕早期超声检测子宫动脉血流参数S/D、RI和PI异常升高,且与不良妊娠结局密切相关,为影响不良妊娠结局的独立危险因素。Objective To investigate the relationship between uterine artery blood flow parameters detected by ultrasound examination during early pregnancy and pregnancy outcomes in pregnant women who had a history of recurrent spontaneous abortion.Methods A total of 100 pregnant women with a history of recurrent spontaneous abortion who were at 6-10 weeks of gestation and received treatment in Zhuji Maternal and Child Health Hospital from June 2020 to June 2022 were included in the study group.Using a case-control study method,100 normal pregnant women who were at 6-10 weeks of gestation who concurrently underwent physical examination were selected and included in the control group.Both groups of pregnant women were tested for uterine artery blood flow parameters using color Doppler ultrasound diagnostic equipment,including peak systolic/diastolic velocity(S/D),resistance index(RI),and pulsatility index(PI).The occurrence of early miscarriage was monitored in both groups.The value of uterine artery blood flow parameters in the prediction of adverse pregnancy outcomes and the correlation between uterine artery blood flow parameters and adverse pregnancy outcomes were analyzed.Multivariate logistic regression was performed to analyze the relationship between uterine artery blood flow parameters and adverse pregnancy outcomes.Results S/D,RI,and PI in the study group were(3.87±0.43),(0.93±0.16),and(1.73±0.41),respectively,which were significantly higher than(2.54±0.37),(0.64±0.14),and(1.24±0.35)in the control group(t=23.44,13.64,9.09,all P<0.05).The early abortion rate in the study group was 57.0%(57/100),which was significantly higher than 2.0%(2/100)in the control group(χ^(2)=72.73,P<0.05).The receiver operating characteristic curve analysis showed that S/D sensitivity and specificity in the prediction of adverse pregnancy outcomes were 79.1%and 70.2%,respectively,RI sensitivity and specificity were 88.4%and 84.2%,respectively,and PI sensitivity and specificity were 65.1%and 75.4%,respectively.Pearson analysis results

关 键 词：妊娠初期 流产 习惯性 子宫动脉 血流动力学检测 妊娠结局 

分 类 号：R714[医药卫生—妇产科学]