基于数据挖掘探讨刘春华治疗原发性高血压病阴虚阳亢证的用药规律  

Medication rule of Liu Chunhua in treatment of primary hypertension with Yin-deficiency and Yang-hyperactivity syndrome:A study based on data mining

作　　者：胡彬[1] 刘春华[2] HU Bin;LIU Chunhua(Hunan University of Chinese Medicine,Changsha 410208,Hunan,China;The Second Affiliated Hospital of Hunan University of Chinese Medicine,Changsha 410005,Hunan,China)

机构地区：[1]湖南中医药大学,湖南长沙410208 [2]湖南中医药大学第二附属医院,湖南长沙410005

出　　处：《湖南中医杂志》2023年第10期19-24,共6页Hunan Journal of Traditional Chinese Medicine

基　　金：湖南省中医药科研计划重点项目(C2022013)。

摘　　要：目的:基于数据挖掘探讨刘春华教授治疗原发性高血压病阴虚阳亢证的用药规律。方法:收集刘教授临床诊治原发性高血压病阴虚阳亢证的有效处方,采用Excel、SPSS Statistics 25.0、SPSS Modeler 18.0软件对中药频次、功效、性味归经、关联规则、聚类进行分析。结果:纳入处方138首,涉及中药194味,其中高频药物21味,功效以补益肝肾、平肝息风为主,药性以平、寒为主,药味以甘、苦为主,多归肝、肺、肾经。关联规则分析得到5组药对,聚类分析得出4组核心药物。结论:刘教授治疗原发性高血压病阴虚阳亢证的用药以补益肝肾、平肝息风为主要治法,兼顾活血、化痰,虚实同治。Objective:To investigate the medication rule of Professor Liu Chunhua in the treatment of primary hypertension with Yin-deficiency and Yang-hyperactivity syndrome based on data mining.Methods:Valid prescriptions were collected from the cases of primary hypertension with Yin-deficiency and Yang-hyperactivity syndrome diagnosed and treated by Professor Liu in clinical practice,and Excel,SPSS Statistics 25.0,and SPSS Modeler 18.0 were used to perform related analyses of traditional Chinese medicine(TCM)drugs in terms of frequency,function,nature/taste/meridian entry,association rule,and cluster analysis.Results:A total of 138 prescriptions were included,involving 194 TCM drugs,among which there were 21 high-frequency drugs,with the main function of tonifying the liver and kidney and pacifying the liver and extinguishing wind.Most drugs had a neutral or cold nature and a sweet or bitter taste,and they mainly entered the liver,lung,and kidney meridians.The association rule analysis obtained 5 drug combinations,and the cluster analysis obtained 4 groups of core drugs.Conclusion:In the treatment of primary hypertension with Yin-deficiency and Yang-hyperactivity syndrome,Professor Liu mainly uses the main therapies of tonifying the liver and kidney and pacifying the liver and extinguishing wind,with consideration to activating blood circulation and resolving phlegm and the treatment of both deficiency and excess.

关 键 词：原发性高血压病 阴虚阳亢证 数据挖掘 用药规律 刘春华 

分 类 号：R259.441.1[医药卫生—中西医结合]