多源信息融合技术在中药质量评价中的应用研究进展  

Research progress of multi-source information fusion technology in quality evaluation of traditional Chinese medicine

作　　者：李涵 谢梦迪 桂新景 侯富国 范雪花 李海洋 王艳丽[2] 李学林[2,3,4,5] 刘瑞新 LI Han;XIE Meng-di;GUI Xin-jing;HOU Fu-guo;FAN Xue-hua;LI Hai-yang;WANG Yan-li;LI Xue-lin;LIU Rui-xin(Henan University of Chinese Medicine,Zhengzhou 450046,China;The First Affiliated Hospital of Henan University of Chinese Medicine,Zhengzhou 450000,China;Henan Province Engineering Research Center for Clinical Application,Evaluation and Transformation of Traditional Chinese Medicine,Zhengzhou 450000,China;Co-construction Collaborative Innovation Center for Chinese Medicine and Respiratory Diseases by Henan&Education Ministry of China,Henan University of Chinese Medicine,Zhengzhou 450000,China;Henan Provincial Key Laboratory for Clinical Pharmacy of Traditional Chinese Medicine,Zhengzhou 450000,China)

机构地区：[1]河南中医药大学,河南郑州450046 [2]河南中医药大学第一附属医院,河南郑州450000 [3]河南省中药临床应用,评价与转化工程研究中心,河南郑州450000 [4]河南中医药大学呼吸疾病中医药防治省部共建协同创新中心,河南郑州450046 [5]河南省中药临床药学中医药重点实验室,河南郑州450000

出　　处：《药学学报》2023年第10期2835-2852,共18页Acta Pharmaceutica Sinica

基　　金：国家自然科学基金资助项目(81773892,81774452);河南省中医药拔尖人才培养项目(重点项目)(2019ZYBJ07);河南省卫生健康中青年学科带头人专项(HNSWJW-2020014);国家中医药管理局2022年青年岐黄学者培养项目(国中医药人教函[2022]256号)。

摘　　要：中药质量评价是关乎中药现代化发展进程的关键问题之一,中药质量评价技术体系主要包括传统评价(性状、显微和理化)、化学评价和生物评价。由于中药组成复杂,上述评价技术体系中的单一检测手段通常无法获得足够的质量信息,信息融合策略可有机整合来自多个分析检测技术的数据,获取样本更全面的信息,提高质量评价效果。目前,信息融合策略已广泛应用于军事、工业和食品等领域,在中药质量评价领域尚处于起步阶段。本文介绍了多源信息融合的定义、结构、方法及融合层次,综述了其在中药产地溯源、品种鉴别和制药分析中的研究进展,并整理了各篇文献中数据融合的具体方法,最后对信息融合技术及其在中药质量评价方面的应用、发展及存在问题进行总结、展望和讨论,以期为拓宽该技术在中医药领域的应用范围提供参考。The quality evaluation of traditional Chinese medicine is one of the key issues related to the modernization of traditional Chinese medicine.The quality evaluation technology system of traditional Chinese medicine mainly includes traditional evaluation(traits,microscopic and physicochemical identification),chemical evaluation and biological evaluation.Due to the complex composition of traditional Chinese medicine,the single detection method in the above evaluation technology system usually cannot obtain sufficient quality information.The multi-source information fusion strategy can organically integrate data from multiple analysis and detection technologies to obtain more comprehensive information of samples and improve the quality evaluation effect.At present,multi-source information fusion strategy has been widely used in the fields of military,industrial and food,and it is still in its infancy in the field of quality evaluation of traditional Chinese medicine.This research introduces the definition,structure,method(algorithm)and fusion level of multi-source information fusion,summarizes its research progress in the origin traceability,variety identification and pharmaceutical analysis of traditional Chinese medicine,and sorts out the specific methods of data fusion in each literature.Finally,we summarized,prospected and discussed the application,development and existing problems of information fusion technology and its application in the quality evaluation of traditional Chinese medicine,in order to provide reference for broadening the application of this technology in the field of traditional Chinese medicine.

关 键 词：中药 质量评价 信息融合 

分 类 号：R286.0[医药卫生—中药学]