醛基化透明质酸/羟丙基壳聚糖自愈合水凝胶的制备与性能  

Preparation and properties of oxidized hyaluronic acid-hydroxypropyl chitosan self-healing hydrogel

作　　者：王艺璇 曲萌菲 张杭 李征征 WANG Yixuan;QU Mengfei;ZHANG Hang;LI Zhengzheng(School of Chemical Engineering and Materials,Tianjin University of Science and Technology,Tianjin 300457,China;State Key Laboratory of Molecular Engineering of Polymers,Fudan University,Shanghai 200433,China)

机构地区：[1]天津科技大学化工与材料学院,天津300457 [2]复旦大学聚合物分子工程国家重点实验室,上海200433

出　　处：《复合材料学报》2023年第10期5884-5891,共8页Acta Materiae Compositae Sinica

基　　金：天津市海洋资源与化学重点实验室(201706);2018年度天津市教委科研计划项目(2018KJ110);天津市制浆造纸重点实验室开放基金资助项目(201809)。

摘　　要：本文通过使用高碘酸钠将透明质酸(HA)上的羟基氧化为醛基,合成醛基化透明质酸(OHA)。以OHA和羟丙基壳聚糖(HPCS)为原料,通过OHA上的醛基与HPCS的氨基发生席夫碱反应生成动态亚胺键,制备了OHA/HPCS自愈合水凝胶。本文通过使用FTIR、UV-vis、SEM、流变和1H NMR对OHA/HPCS自愈合水凝胶的微观形貌与性能进行表征与探究。OHA/HPCS水凝胶具有多孔结构,孔径范围在70~200μm之间。随着OHA用量的增加,OHA/HPCS水凝胶内部的孔隙增多,孔径变小,OHA/HPCS的溶胀比逐渐变小,且降解速率变缓。在室温且无外界刺激的条件下,OHA/HPCS水凝胶在4 h内能够实现自愈合。OHA/HPCS水凝胶能够缓慢释放抗癌药物吉西他滨,药物累计释放率为70%~84%,释放时间为12天。OHA/HPCS水凝胶具有缓慢释放吉西他滨的性能,表明OHA/HPCS水凝胶在药物释放领域具有潜在的应用前景。In this paper,oxidized hyaluronic acid(OHA)was synthesized by oxidizing hydroxyl groups on hyaluronic acid(HA)with sodium periodate.OHA/HPCS self-healing hydrogel was prepared by using OHA and hydroxypropyl chitosan(HPCS)as raw materials.The aldehyde group on OHA reacted with the amino group of HPCS to form dynamic imine bond through Schiff base reaction.In this paper,the microscopic morphology and properties of OHA/HPCS self-healing hydrogel was characterized by FTIR,UV-vis,SEM,rheology and 1H NMR.OHA/HPCS hydrogels have a porous structure,and the results show that the pore size ranged from 70 to 200µm by changing the amount of OHA.With the increase of the dosage of OHA,the pores in the OHA/HPCS hydrogels increase,the pore size becomes smaller,the swelling ratio of OHA/HPCS becomes smaller,and the degradation rate becomes slower.OHA/HPCS hydrogel can self-heal within 4 h at room temperature without external stimulation.OHA/HPCS hydrogel can release anticancer drug of gemcitabine in sustained way,with a cumulative release percent of 70%-84%in 12 days.OHA/HPCS hydrogels have the properties of sustained release gemcitabine,indicating that OHA/HPCS hydrogels have potential application prospects in the field of drug release.

关 键 词：醛基化透明质酸 羟丙基壳聚糖 自愈合 水凝胶 药物释放 

分 类 号：O63[理学—高分子化学] TB332[理学—化学]