补肾疏肝类中药治疗排卵障碍性不孕的系统评价  

Systematic Review of Bushen Shugan Traditional Chinese Medicine in the Treatment of Ovulation Disorder Infertility

作　　者：杨易 隋娟 任梦雪 毕红[2] 陈瑞雪[2] YANG Yi;SUI Juan;REN Mengxue;BI Hong;CHEN Ruixue(Graduate School,Beijing University of Chinese Medicine,Beijing 100029,China;Dept.of Gynecology,Guang’anmen Hospital,China Academy of Chinese Medical Sciences,Beijing 100053,China)

机构地区：[1]北京中医药大学研究生院,北京100029 [2]中国中医科学院广安门医院妇科,北京100053

出　　处：《中国医院用药评价与分析》2023年第9期1105-1108,1113,共5页Evaluation and Analysis of Drug-use in Hospitals of China

基　　金：国家自然科学基金项目(No.82274574);中央本级重大增减支项目(No.2060302);中国中医科学院科技创新工程项目(No.CI2021A02407)。

摘　　要：目的:基于循证研究的方法,对补肾疏肝类中药治疗排卵障碍性不孕的有效性进行系统评价。方法:计算机检索中国知网、万方数据库、中国生物医学文献数据库、维普数据库、the Cochrane Library、PubMed、Embase和Web of Science等8个数据库,检索时间为建库至2022年4月19日,选取补肾疏肝类中药治疗排卵障碍性不孕的临床随机对照试验。根据纳入标准和排除标准对文献进行筛选,采用“偏移风险评估工具”进行质量评价。运用RevMan 5.3软件对结局指标进行Meta分析。结果:最终纳入研究14项,患者共1 249例。Meta分析结果显示,与单纯使用枸橼酸氯米芬比较,补肾疏肝类中药联合枸橼酸氯米芬治疗排卵障碍性不孕患者,在提高妊娠率(RR=1.96,95%CI=1.67~2.29,P<0.000 01)、排卵率(RR=1.39,95%CI=1.25~1.55,P<0.000 01)和有效率(RR=1.31,95%CI=1.21~1.42,P<0.000 01),增加优势卵泡直径(MD=2.45,95%CI=1.56~3.33,P<0.000 01)方面有优势,差异均有统计学意义。结论:临床使用补肾疏肝类中药治疗排卵障碍性不孕可以取得较好疗效。OBJECTIVE:To systematically review the efficacy of Bushen Shugan traditional Chinese medicine in the treatment of ovulation disorder infertility based on methods of evidence-based research.METHODS:CNKI,Wanfang Data,CBM,VIP,the Cochrane Library,PubMed,Embase and Web of Science were retrieved to extract clinical randomized controlled trial of Bushen Shugan traditional Chinese medicine in the treatment of ovulation disorder infertility.The retrieval time was from the establishment of the database to Apr.19th,2022.Literature was screened according to inclusion criteria and exclusion criteria,and the “bias risk assessment tool” was used for quality evaluation.Meta-analysis of outcome was performed by using RevMan 5.3 software.RESULTS:Totally 14 RCT studies were enrolled,including 1 249 patients.Meta-analysis showed that compared with clomifene citrate alone,the combination of Bushen Shugan traditional Chinese medicine with clomifene citrate in the treatment of patients with ovulation disorder infertility increased the pregnancy rate(RR=1.96,95%CI=1.67-2.29,P<0.000 01),ovulation rate(RR=1.39,95%CI=1.25-1.55,P<0.000 01) and effective rate(RR=1.31,95%CI=1.21-1.42,P<0.000 01),and improved the dominant follicle diameter(MD=2.45,95%CI=1.56-3.33,P<0.000 01),the differences were statistically significant.CONCLUSIONS:Clinical application ofBushen Shugan traditional Chinese medicine in the treatment of patients with ovulation disorder infertility can obtain better curative effect.

关 键 词：排卵障碍性不孕 补肾疏肝类中药 META分析 系统评价 

分 类 号：R932[医药卫生—生药学]