奥美拉唑静滴治疗小儿上消化道出血临床效果分析  

Analysis of the clinical effect of intravenous omeprazole on children's Upper gastrointestinal bleeding

作　　者：张佳航[1] ZHANG Jiahang(Jixi People's Hospital,Jixi,Heilongjiang 158100,China)

机构地区：[1]鸡西市人民医院,黑龙江鸡西158100

出　　处：《中国国境卫生检疫杂志》2023年第S02期79-81,共3页Chinese Journal of Frontier Health and Quarantine

摘　　要：目的探讨奥美拉唑静滴治疗小儿上消化道出血临床效果。方法选择96例上消化道出血患儿,随机分为观察组(48例)和对照组(48例),分别给予奥美拉唑和西咪替丁静脉滴注。结果观察组治疗有效率为93.75%,对照组为77.08%(P<0.05);观察组止血时间、输血量、隐血试验转阴时间、肿瘤坏死因子-α、丙二醛水平低于对照组(P<0.05);血管内皮生长因子、超氧化物歧化酶水平高于对照组(P<0.05);观察组再出血率、不良反应发生率分别为2.08%、4.17%,均低于对照组(14.58%、18.75%)(P<0.05)。结论奥美拉唑静滴可提高小儿上消化道出血的止血效果,缩短止血时间,降低再出血发生率。Objective To investigate the clinical effect of omeprazole in treating upper gastrointestinal bleeding in children.Methods 96 children with upper gastrointestinal bleeding were randomly divided into observation group(48 patients)and control group(48 patients),and were given intravenous omeprazole and cimetidine,respectively.Results The efficiency was 93.75%,77.08%(P<0.05),hemostasis time,transfusion,TNF-α and malondialdehyde were lower,vascular endothelial growth factor and superoxide dismutase were higher(P<0.05),and 2.08% and 4.17%were lower than controls(14.58%,18.75%)(P<0.05).Conclusion Omeprazole can improve the hemostasis effect of upper gastrointestinal bleeding,shorten the hemostasis time and reduce the incidence of rebleeding.

关 键 词：奥美拉唑 西咪替丁 上消化道出血 

分 类 号：R183[医药卫生—流行病学]