Scutellarin attenuates microglia activation in experimentally induced hypoxia-ischemia brain damage by down-regulating miRNA-7036a  

作　　者：Wenji Jia Yun Yuan Li Yang Chunyun Wu 

机构地区：[1]Department of Anatomy and Histology/Embryology,Faculty of Basic Medical Sciences,Kunming Medical University,Kunming 650500,China [2]Department of Neurology,No.2 Affiliated Hospital,Kunming Medical University,Kunming 650101,China

出　　处：《Acta Biochimica et Biophysica Sinica》2023年第10期1685-1688,共4页生物化学与生物物理学报（英文版）

基　　金：supported by the grants from the National Natural Science Foundation of China(No.81960223 to C.W.);Applied Basic Research Projects of Yunnan Province(No.202001AY070001-217 to W.J.).

摘　　要：Neonatal hypoxic-ischemic encephalopathy(HIE)is widely acknowledged to cause acute neonatal death and chronic neurological injury[1].Currently,there is no effective treatment for neonatal hypoxia-ischemia brain damage(HIBD)[2].Therefore,it is desirable to search for more effective strategies to alleviate longterm neurological deficits caused by HIE.Microglia is crucial to promote the development and homeostasis of the central nervous system(CNS)during early embryonic stage[3].

关 键 词：damage ISCHEMIA HIE 

分 类 号：R722.12[医药卫生—儿科]