孕妇的碘营养状况对新生儿甲状腺功能的影响  

Effects of maternal iodine nutrition status on neonatal thyroid function

作　　者：杜丽伟 陈相 周明德 王成 卢文深 DU Liwei;CHEN Xiang;ZHOU Mingde;WANG Cheng;LU Wenshen(Department of Clinical Laboratory,Luohu Maternal and Child Health Hospital,Shenzhen,Guangdong 518019,China;Center of Laboratory Medicine,Shenzhen Luohu Hospital Group,Shenzhen,Guangdong 518000,China)

机构地区：[1]广东省深圳市罗湖区妇幼保健院检验科,广东深圳518019 [2]深圳市罗湖医院集团医学检验中心,广东深圳518000

出　　处：《检验医学与临床》2023年第22期3309-3312,共4页Laboratory Medicine and Clinic

基　　金：2021年广东省深圳市罗湖区科技创新局资助项目(Lx20210509)。

摘　　要：目的探讨孕妇孕晚期的碘营养状况对新生儿甲状腺功能的影响。方法选择广东省深圳市罗湖区妇幼保健院收治的孕晚期检查及分娩的308名孕妇作为研究对象,对孕妇及其分娩的足月、正常新生儿进行尿碘检测,并根据孕妇不同碘营养状况分为碘缺乏组、碘正常组、碘过量组,采集孕妇孕晚期静脉血进行甲状腺激素检测,采集新生儿的足跟血进行促甲状腺素(TSH)检测。结果碘缺乏组、碘正常组和碘过量组孕妇游离三碘甲状腺原氨酸(FT3)、游离甲状腺激素(FT4)、TSH水平比较,差异无统计学意义(P>0.05)。不同碘营养状况孕妇分娩的新生儿缺碘率比较,差异有统计学意义(P<0.05)。孕妇尿碘水平与新生儿缺碘率呈负相关(r=-0.776,P<0.05)。不同碘营养状况孕妇分娩的新生儿尿碘、TSH水平比较,差异无统计学意义(P>0.05)。结论孕晚期孕妇甲状腺功能均在正常范围内,其新生儿的甲状腺功能保持正常,提示若母体缺碘在一定范围内,胎儿可能通过某种自身保护机制使其甲状腺激素水平维持在正常范围内。Objective To investigate the effect of iodine nutrition status late pregnancy on neonatal thyroid function.Methods A total of 308 pregnant women admitted to Luohu Maternal and Child Health Hospital for late pregnancy examination and delivery were selected as the study subjects.Urine iodine detection was performed on the pregnant women and full-term normal newborns,and the pregnant women were divided into iodine deficiency group,iodine normal group and iodine excess group according to the different iodine nutritional status,and thyroid hormone detection was performed in pregnant women.Heel blood of newborns was collected for thyroid stimulating hormone(TSH)detection.Results There was no significant difference on the levels of free triiodothyronine(FT3),free thyroid hormone(FT4)and TSH in the iodine deficiency group,iodine normal group and iodine excess group(P>0.05).There was a statistically significant difference on the iodine deficiency rate of newborns among pregnant women with different iodine nutritional status(P<0.05).The urinary iodine level of pregnant women correlated negatively with the iodine deficiency rate of newborns(r=-0.776,P<0.05).There was no statistically significant difference on urinary iodine and TSH levels of newborns(P>0.05).Conclusion The thyroid function of the pregnant women in the third trimester is within the normal range,and the thyroid function of the newborns remains normal,suggesting that if the iodine deficiency of the mother is within a certain range,the fetus may maintain its thyroid hormone level within the normal range through some self-protection mechanism.

关 键 词：碘营养 甲状腺功能 尿碘 

分 类 号：R446.1[医药卫生—诊断学]