补肾健脾方辅助治疗阿尔茨海默病的效果及对患者肠道菌群微生态、脑干诱发电位的影响  

Effect of Bushen Jianpi decoction in the adjuvant treatment of Alzheimer's disease and its effect on the intestinal flora microecology and brainstem evoked potential of patient

作　　者：张茜 郭王斌 ZHANG Qian;GUO Wangbin(Department of Geriatrics,Xi'an Traditional Chinese Medicine Hospital,Xi'an,Shaanxi 710021,China)

机构地区：[1]陕西省西安市中医医院老年病科,陕西西安710021

出　　处：《检验医学与临床》2023年第22期3352-3356,共5页Laboratory Medicine and Clinic

摘　　要：目的探讨阿尔茨海默病(AD)应用补肾健脾方辅助治疗的效果及对患者肠道菌群微生态、脑干诱发电位的影响。方法选取2018年8月至2021年8月该院92例AD患者为研究对象,按照随机数字表法分为对照组和观察组,每组46例,给予对照组常规西药治疗,观察组在对照组基础上加用补肾健脾方治疗,比较两组疗效,并于治疗前、治疗3个月后、治疗6个月后比较两组脑干诱发电位、阿尔茨海默病评定量表-认知部分(ADAS-cog)评分、简易智能精神状态检查量表(MMSE)评分、日常生活能力量表(ADL)评分、肠道菌群微生态及血清炎症因子[白细胞介素-6(IL-6)、IL-1β、肿瘤坏死因子-α(TNF-α)]水平。结果治疗6个月后观察组总有效率为93.48%,明显高于对照组的73.91%,差异有统计学意义(P<0.05);治疗3个月后、治疗6个月后观察组波Ⅴ波幅高于对照组,波Ⅴ潜伏期短于对照组,差异有统计学意义(P<0.05);波Ⅴ波幅、波Ⅴ潜伏期,ADAS-Cog评分、MMSE评分、ADL评分,乳酸杆菌、酵母菌、肠球菌、双歧杆菌、消化球菌、大肠杆菌数量,IL-6、IL-1B、TNF-α水平的变化存在组间效应、时间效应、交互效应(P<0.05);治疗3个月后、治疗6个月后观察组ADAS-Cog、ADL评分低于对照组,MMSE评分高于对照组,差异有统计学意义(P<0.05);治疗3个月后、6个月后观察组乳酸杆菌、双歧杆菌、酵母菌、消化球菌菌群数量大于对照组,大肠杆菌、肠球菌菌群数量少于对照组,差异有统计学意义(P<0.05);治疗3个月后、治疗6个月后观察组血清IL-6、IL-1β、TNF-α水平低于对照组,差异有统计学意义(P<0.05)。结论补肾健脾方辅助治疗AD患者效果明显,可有效改善肠道菌群微生态、脑干诱发电位,减轻炎症反应,提高日常生活能力。Objective To investigate the effect of Bushen Jianpi decoction in the adjuvant treatment of Alzheimer's disease(AD)and its influence on the intestinal flora microecology and brainstem evoked potential of patients.Methods A total of 92 cases of AD patients in Xi'an Traditional Chinese Medicine Hospital from August 2018 to August 2021 were selected as research objects,and were divided into control group and observation group according to random number table method,with 46 cases in each group.The control group was given conventional western medicine treatment,and the observation group was treated with Bushen Jianpi decoction on the basis of the control group.The efficacy of the two groups was compared.Brainstem evoked potential,Alzheimer's Disease Rating Scale-Cognitive Component(ADAS-cog)score,Simple Intelligent Mental State Examination Scale(MMSE)score,Daily Living Ability Scale(ADL)score,intestinal flora microecology and serum levels of inflammatory factors[interleukin-6(IL-6),IL-1β,tumor necrosis factor-α(TNF-α)]were compared between the two groups before treatment,3 months after treatment and 6 months after treatment.Results After 6 months of treatment,the total effective rate of the observation group was 93.48%,which was significantly higher than that of the control group(73.91%),the difference was statistically significant(P<0.05).After 3 months and 6 months of treatment,the amplitude of waveⅤin observation group was higher than that in control group,and the latency of waveⅤwas shorter than that in control group,the difference was statistically significant(P<0.05).WaveⅤamplitude,waveⅤlatency,ADAS-Cog score,MMSE score,ADL score,the number of Lactobacillus,Yeast,Enterococcus,Bifidobacterium,Peptococcus,Escherichia coli,IL-6,IL-1B and TNF-αlevels had intergroup effect,time effect and interaction effect(P<0.05).After 3 months and 6 months of treatment,the ADAS-Cog and ADL scores of the observation group were lower than those of the control group,and the MMSE score was higher than that of the control g

关 键 词：阿尔茨海默病 补肾健脾方 肠道菌群微生态 脑干诱发电位 炎症因子 

分 类 号：R287[医药卫生—中药学]