骨化三醇联合骨疏康胶囊对骨质疏松症患者血清OPG、BGP水平的影响  

Effect of calcitriol combined with Gushukang capsule on serum OPG and BGP levels in patients with osteoporosis

作　　者：杨盼盼 胡俊[1] 叶小青 谈荣珍 张斌[1] 袁忠[1] YANG Panpan;HU Jun;YE Xiaoqing;TAN Rongzhen;ZHANG Bin;YUAN Zhong(Department of Osteoporosis,Nanchang Hongdu Traditional Chinese Medicine Hospital,Nanchang,Jiangxi 330013,China;Department of Nephrology,Nanchang Hongdu Traditional Chinese Medicine Hospital,Nanchang,Jiangxi 330013,China)

机构地区：[1]江西省南昌市洪都中医院骨质疏松科,江西南昌330013 [2]江西省南昌市洪都中医院肾内科,江西南昌330013

出　　处：《检验医学与临床》2023年第22期3383-3385,共3页Laboratory Medicine and Clinic

摘　　要：目的观察骨化三醇联合骨疏康胶囊对骨质疏松症(OP)患者血清骨保护素(OPG)、骨钙素(BGP)水平的影响。方法将该院收治的OP患者84例按照随机数字表法分为观察组与对照组,各42例。对照组采用骨化三醇治疗,在此基础上,观察组联合骨疏康胶囊治疗,连续治疗6个月。比较两组临床疗效、血清学指标、骨密度及不良反应。结果观察组与对照组治疗总有效率分别为78.57%、95.24%,观察组明显高于对照组,差异有统计学意义(P<0.05);治疗后两组OPG、BGP水平,以及股骨颈L1~4骨密度均升高,且观察组改善更明显(P<0.05)。结论骨化三醇联合骨疏康胶囊治疗可有效调节OP患者血清OPG、BGP水平,促进骨密度的增加,效果较好,且联合治疗具有较高安全性。Objective To observe the effects of calcitriol combined with Gushukang capsule on serum osteopalcin(OPG)and osteocalcin(BGP)levels in patients with osteoporosis(OP).Methods A total of 84 OP patients admitted to Nanchang Hongdu Traditional Chinese Medicine Hospital were divided into observation group and control group according to the random number table methods,42 cases in each group.The control group was treated with calcitriol,and on this basis,the observation group was treated with Gushukang capsule for 6 months.The clinical efficacy,serological parameters,bone mineral density and adverse effects were compared between the two groups.Results The total effective rate of the observation group(78.57%)was significantly higher than that of the control group(95.24%)(P<0.05).After treatment,the levels of OPG,BGP and bone mineral density of femoral neck and L1-4 in both groups increased,the improvement was also more significant in the observation group(P<0.05).Conclusion Calcitriol combined with Gushukang capsule can effectively increase the level of serum OPG and BGP in OP patients,promote the improvement of bone mineral density,and the combined treatment has high safety.

关 键 词：骨质疏松症 骨化三醇 骨疏康胶囊 骨保护素 骨钙素 

分 类 号：R580[医药卫生—内分泌]