重视呼吸道人副流感病毒感染  

Pay attention to respiratory infections caused by human parainfluenza virus

作　　者：朱云[1,2] 谢正德 Zhu Yun;Xie Zhengde(Laboratory of Infection and Virology,Beijing Pediatric Research Institute,Beijing Key Laboratory of Pediatric Respiratory Infection Diseases,Beijing Children’s Hospital,Capital Medical University,Key Laboratory of Major Diseases in Children,Ministry of Education,National Clinical Research Center for Respiratory Diseases,National Center for Children’s Health,Beijing 100045,China;Research Unit of Critical infection in Children,Chinese Academy of Medical Sciences,2019RU016,Beijing 100045,China)

机构地区：[1]国家儿童医学中心,国家呼吸系统临床医学研究中心,首都医科大学附属北京儿童医院,儿科重大疾病研究教育部重点实验室,儿童呼吸道感染性疾病研究北京市重点实验室,北京市儿科研究所,感染与病毒研究室,北京100045 [2]中国医学科学院儿童危重感染诊治创新单元,2019RU016,北京100045

出　　处：《中华实验和临床病毒学杂志》2023年第5期469-471,共3页Chinese Journal of Experimental and Clinical Virology

基　　金：中国医学科学院医学与健康科技创新工程(2019-I2M-5-026);国家科技重大专项(2017ZX10103004-004);首都卫生发展科研专项公共卫生项目(首发2021-1G-3012)。

摘　　要：人副流感病毒(human parainfluenza viruses,HPIVs)属于副黏病毒科,为有包膜的单股负链RNA病毒,根据其血清学及基因组特征,分为HPIV1-4型。HPIVs是引起儿童和成人急性呼吸道感染的重要病毒病原,其疾病负担可能被严重低估。目前HPIVs感染尚无有效的疫苗和特异的抗病毒药物,需要重视HPIVs感染的病原学监测、致病机制研究、疾病诊治、抗病毒药物和疫苗的研发。Human parainfluenza viruses(HPIVs)are enveloped,single-stranded RNA viruses in the Paramyxoviridae family with four antigenically and genetically distinct types,HPIV1-4.HPIVs are important viral agents that cause acute respiratory infections in children and adults,and disease burden of HPIVs infection may be significantly underestimated.Currently,there are no effective vaccines and antivirals for prophylaxis and treatment of HPIVs infection.Attention needs to be paid to the pathogenic monitoring,pathogenesis,disease diagnosis and treatment,as well as the development of antiviral drugs and vaccines for HPIVs infection.

关 键 词：人副流感病毒 病原学 疫苗 抗病毒药物 

分 类 号：R511.7[医药卫生—内科学]