基于“阴火”理论与胃癌能量代谢、酸性微环境的关系探讨胃癌的中医治疗  

TCM treatment of gastric cancer based on the relationship between"Yin Fire"Theory and energy metabolism-acidic microenvironment

作　　者：梁阳月盈 廖冬颖 苏畅[1,2] 李悦[3] 孔凡铭[1,2] LIANG Yangyueying;LIAO Dongying;SU Chang;LI Yue;KONG Fanming(The First Hospital of Tianjin University of Chinese Medicine,Tianjin 300381,China;Tianjin University of Chinese Medicine,Tianjin 301617,China;Tianjin Heping District Hospital of Chinese Medicine,Tianjin 300020,China)

机构地区：[1]天津中医药大学第一附属医院,天津300381 [2]天津中医药大学,天津301617 [3]天津市和平区中医医院,天津300020

出　　处：《湖南中医药大学学报》2023年第11期2104-2111,共8页Journal of Hunan University of Chinese Medicine

基　　金：国家重点研发计划项目(2018YFC1707400)。

摘　　要：以李杲的“阴火”理论为基础,从中医学角度分析胃癌的发病机制和辨证治法,认为元气虚损是胃癌发生的基础,气火失调,痰、气、瘀蕴结是胃癌发展的病因。胃癌的发生与脾胃内伤化火有关,阴火与肿瘤的能量代谢和酸性微环境有着密切联系。从中医典籍中溯源阴火,阐释“阴火”学说的理论内涵,对阴火致病与胃癌形成的生理、病理变化做出总结分析,并提出中医治疗胃癌的原则和方法。在治疗上,应用“升阳散火”之法,既能补中升阳,又能泻火清热,达到调整气机、消除阴火、抑制肿瘤的目的。为胃癌的中医治疗提供新的思路和理论依据,也为“阴火”理论的临床应用拓展了新的领域。此外,对“阴火”理论与胃癌的能量代谢、酸性微环境的关系进行探讨,指出两者之间的相似性和互补性,为中西医结合治疗胃癌提供新视角和可能性。The pathogenesis,and treatment of gastric cancer is analyzed based on LI Gao's"Yin Fire"Theory from the perspective of Chinese medicine.The foundamental factor of gastric cancer is the deficiency of vital energy,and the causes are the imbalance of qi and fire,and the accumulation of phlegm,qi,and stagnation.It is also related to internal injury of the spleen and stomach transforming into fire."Yin Fire"is closely related to tumors'energy metabolism and acidic microenvironment.This paper has traced back to Yin Fire from ancient Chinese medical books,explained the theoretical connotation of Yin Fire doctrine,summarized and analyzed the physiological and pathological changes caused by Yin Fire and gastric cancer,and put forward the principles and methods of TCM treatment.The method of"ascending yang to disperse fire"is applied,which can replenish yang in the spleen and stomach,but also reduce fire and clear heat,thus adjusting qi movement,eliminating Yin Fire,and suppressing tumors.These have provided a new idea and theoretical basis for the treatment of gastric cancer in Chinese medicine,and expands a new field for the clinical application of"Yin Fire"Theory.In addition,it also discusses the relationship between the"Yin Fire"Theory and the energy metabolism-acidic microenvironmen of gastric cancer,then points out their similarities,differences,and complementarity,providing a new perspective and possibility for the combined treatment of gastric cancer by integrating Chinese and Western medicine.

关 键 词：胃癌 阴火 脾胃气虚 甘温除热 升阳散火 李杲 

分 类 号：R273[医药卫生—中西医结合]