双重抗血小板联合丙种球蛋白治疗小儿川崎病的效果及对血小板活性、冠脉损伤标志物的影响  

Effect of double antiplatelet combined with gamma globulin in the treatment of children with Kawasaki disease and its influences on platelet activity and coronary artery injury markers

作　　者：王娜 王妍 严晓华[3] WANG Na;WANG Yan;YAN Xiaohua(Xi'an No.9 Hospital,Xi'an 710054;Xi'an Fifth Hospital,Xi'an 710082;Shaanxi Provincial People's Hospital,Xi'an 710068,China)

机构地区：[1]西安市第九医院,陕西西安710054 [2]西安市第五医院,陕西西安710082 [3]陕西省人民医院,陕西西安710068

出　　处：《临床医学研究与实践》2023年第33期31-34,共4页Clinical Research and Practice

基　　金：陕西省重点研发计划项目(No.2019SF-112)。

摘　　要：目的探讨双重抗血小板联合丙种球蛋白治疗小儿川崎病的效果及对血小板活性、冠脉损伤标志物的影响。方法选取2020年2月至2021年4月收治的90例川崎病患儿为研究对象,根据不同的治疗方案将其分为对照组和观察组,每组45例。对照组采用阿司匹林联合丙种球蛋白治疗,观察组采用双重抗血小板联合丙种球蛋白治疗。比较两组的治疗效果。结果观察组的治疗总有效率高于对照组,差异具有统计学意义(P<0.05)。治疗后,观察组的血小板活化因子(PAF)、血小板反应蛋白-1(TSP-1)水平低于对照组,差异具有统计学意义(P<0.05)。治疗后,观察组的肌酸激酶同工酶(CK-MB)、心肌肌钙蛋白I(cTnI)、C反应蛋白(CRP)、N-末端脑钠肽前体(NT-proBNP)水平低于对照组,差异具有统计学意义(P<0.05)。结论双重抗血小板联合丙种球蛋白治疗小儿川崎病的效果显著,不仅能够有效抑制血小板活性,还能减轻冠脉损伤程度,促进机体恢复,值得推广。Objective To study the effect of double antiplatelet combined with gamma globulin in the treatment of children with Kawasaki disease and its influences on platelet activity and coronary artery injury markers.Methods Ninety children with Kawasaki disease treated from February 2020 to April 2021 were selected as the study objects and divided into control group and observation group according to the different treatment plan,with 45 cases in each group.The control group was treated with aspirin combined with gamma globulin,and the observation group was treated with double antiplatelet combined with gamma globulin.The therapeutic effects of the two groups were compared.Results The total effective rate of treatment in the observation group was higher than that in the control group,and the difference was statistically significant(P<0.05).After treatment,the levels of platelet activating factor(PAF)and thrombospondin-1(TSP-1)in the observation group were lower than those in the control group,and the differences were statistically significant(P<0.05).After treatment,the levels of creatine kinase isoenzymes(CK-MB),cardiac troponin I(cTnI),C-reactive protein(CRP)and N-terminal pro-brain natriuretic peptide(NT-proBNP)in the observation group were lower than those in the control group,and the differences were statistically significant(P<0.05).Conclusion The double antiplatelet combined with gamma globulin has a remarkable effect in the treatment of children with Kawasaki disease,it not only can effectively inhibit platelet activity,but also can reduce the coronary artery injury degree and promote body recovery,which is worth promoting.

关 键 词：双重抗血小板 丙种球蛋白 川崎病 血小板活性 冠脉损伤标志物 

分 类 号：R725.6[医药卫生—儿科]