达格列净治疗射血分数降低心力衰竭并植入心脏除颤起搏器患者的效果及对心功能、室性心律失常的影响  

Effect of dapagliflozin in the treatment of heart failure with reduced ejection fraction and implantation of cardiac defibrillator pacemaker and its influences on cardiac function and ventricular arrhythmia

作　　者：朱艾华 李朝亮 ZHU Aihua;LI Chaoliang(Jinxiang People's Hospital,Jining 272200;the 7th People's Hospital of Zhengzhou,Zhengzhou 450000,China)

机构地区：[1]金乡县人民医院,山东济宁272200 [2]郑州市第七人民医院,河南郑州450000

出　　处：《临床医学研究与实践》2023年第33期83-86,共4页Clinical Research and Practice

摘　　要：目的分析达格列净治疗射血分数降低心力衰竭并植入心脏除颤起搏器患者的效果及对心功能、室性心律失常的影响。方法纳入2019年8月至2021年8月收治的90例射血分数降低心力衰竭并植入心脏除颤起搏器患者为研究对象,按照随机数字表法将其分为对照组和观察组,各45例。对照组采用标准化药物治疗,观察组在对照组基础上加达格列净治疗。比较两组的治疗效果。结果用药后,观察组的左室射血分数高于对照组,左室舒张末期内径和左室收缩末期内径低于对照组(P<0.05)。观察组的室性心律失常总发生率低于对照组(P<0.05)。用药后,观察组的N末端B型利钠肽原和血浆脑钠肽水平低于对照组(P<0.05)。用药后,观察组的体力、病情、一般生活、社会心理状况评分和总分高于对照组(P<0.05);用药后,两组的医疗状况、工作状况评分无明显差异(P>0.05)。结论达格列净治疗射血分数降低心力衰竭并植入心脏除颤起搏器患者的效果满意,有利于改善心功能,降低室性心律失常和心肌细胞损伤的发生风险,改善患者的生活质量,值得推广。Objective To analyze the effect of dapagliflozin in the treatment of heart failure with reduced ejection fraction and implantation of cardiac defibrillator pacemaker and its influences on cardiac function and ventricular arrhythmia.Methods A total of 90 patients with heart failure with reduced ejection fraction and implanted with cardiac defibrillator pacemaker admitted from August 2019 to August 2021 were included in the study as the study subjects.According to the random number table method,the patients were divided into control group and observation group,with 45 cases in each group.The control group was treated with standardized drugs,and the observation group was treated with dapagliflozin on the basis of the control group.The therapeutic effect of two groups were compared.Results After medication,the left ventricular ejection fraction of the observation group was higher than that of the control group,and the left ventricular end-diastolic diameter and left ventricular end-systolic diameter were lower than those of the control group(P<0.05).The total incidence of ventricular arrhythmia in the observation group was lower than that in the control group(P<0.05).After medication,the levels of N-terminal B-type natriuretic peptide and plasma brain natriuretic peptide in the observation group were lower than those in the control group(P<0.05).After medication,the physical strength,illness,general life,social psychological status scores and total score in the observation group were higher than those in the control group(P<0.05);after medication,there were no significant differences in the scores of medical status and working status between the two groups(P>0.05).Conclusion Dapagliflozin in the treatment of heart failure with reduced ejection fraction and implantation of cardiac defibrillation pacemaker has satisfactory effect,it is beneficial to improve cardiac function,reduce the risk of ventricular arrhythmia and myocardial cell injury,and improve the quality of life of patients,which is worthy of promotion.

关 键 词：射血分数降低 心力衰竭 达格列净 心功能 室性心律失常 心脏除颤起搏器 

分 类 号：R541.6[医药卫生—心血管疾病]