化裁顾步汤治疗脉络瘀热证FontaineⅡ~Ⅲ期下肢动脉硬化闭塞症疗效观察  

Efficacy of modified Gubu Decoction on FontaineⅡ-Ⅲarteriosclerosis obliterans of lower limbs with syndrome of blood stasis and heat in the collaterals

作　　者：铁一夫 赵钢[1] 于杰 TIE Yifu;ZHAO Gang;YU Jie(The First Affiliated Hospital of Heilongjiang University of Chinese Medicine,Harbin 150040,Heilongjiang,China;Suqian First People’s Hospital Affiliated to Nanjing Medical University,Suqian 223800,Jiangsu,China;Heilongjiang University of Chinese Medicine,Harbin 150040,Heilongjiang,China)

机构地区：[1]黑龙江中医药大学附属第一医院,黑龙江哈尔滨150040 [2]南京医科大学附属宿迁第一人民医院,江苏宿迁223800 [3]黑龙江中医药大学,黑龙江哈尔滨150040

出　　处：《现代中西医结合杂志》2023年第18期2504-2508,2513,共6页Modern Journal of Integrated Traditional Chinese and Western Medicine

基　　金：中国博士后科学基金资助项目(2021MD703836);宿迁市“西楚英才”雄英计划双创人才资助项目(卫生创新)〔(2022)-0051〕。

摘　　要：目的观察化裁顾步汤治疗脉络瘀热证下肢动脉硬化闭塞症的临床效果,评价其安全性及有效性。方法将2022年1—12月黑龙江中医药大学附属第一医院诊治的48例脉络瘀热证FontaineⅡ~Ⅲ期下肢动脉硬化闭塞症患者随机分为2组,2组均给予常规基础治疗,观察组在此基础上给予化裁顾步汤口服,对照组给予通塞脉片口服,2组均以28 d为1个疗程。观察2组患者治疗前后临床症状体征(皮肤色泽、疼痛感、间歇性跛行距离、间歇性跛行缓解时间)评分、血纤维蛋白原(FIB)水平、血浆D-二聚体(D-dimer)水平、血白细胞计数(WBC)变化,比较2组总体疗效及安全性。结果2组治疗后各临床症状体征评分及总评分、FIB水平、D-dimer水平、WBC计数均较治疗前明显降低(P均<0.05),且观察组各临床症状体征评分及总评分、FIB水平、D-dimer水平、WBC计数均明显低于对照组(P均<0.05)。观察组总有效率明显高于对照组[83.3%(20/24)vs 66.7%(16/24)](P<0.05)。2组治疗过程中均无不良反应发生。结论化裁顾步汤治疗脉络瘀热证FontaineⅡ~Ⅲ期下肢动脉硬化闭塞症安全有效,临床效果明显优于通塞脉片。Objective It is to observe the clinical effect of modified Gubu Decoction on arteriosclerosis obliterans of lower limbs with syndrome of blood stasis and heat in the collaterals,and evaluate its safety and effectiveness.Methods Forty-eight patients with lower limbs arteriosclerosis obliterans(stageⅡ-Ⅲ)with with syndrome of blood stasis and heat in the collaterals diagnosed and treated in the First Affiliated Hospital of Heilongjiang University of Chinese Medicine from January 2022 to December 2022 were randomly divided into observation group and control group,with 24 cases in each group.Both groups were given routine basic therapy,the observation group was treated with modified Gubu Decoction by oral administration,the control group was given Tongsaimai tablets by oral administration.28 days as one treatment course in both groups.The changes in the scores of clinical symptoms and signs(skin color,pain,intermittent claudication distance,intermittent claudication relief time),the levels of blood fibrinogen(FIB),plasma D-dimer(D-dimer)and blood leukocyte count(WBC)of patients in both groups were observed before and after the treatment,and the overall efficacy and safety of the two groups were compared.Results After treatment,the scores of every clinical sign and symptom and total scores,the levels of FIB,D-dimer and WBC of the two groups were significantly decreased compared with before treatment(P<0.05),and the scores of every clinical sign and symptom and total scores,the levels of FIB,D-dimer and WBC of the observation group were significantly lower than those of the control group(all P<0.05).The total effective rate of the observation group was significantly higher than that of the control group[83.3%(20/24)vs 66.7%(16/24)](P<0.05).No adverse reactions occurred during the treatment in both groups.Conclusion Modified Gubu Decoction is safe and effective in the treatment of arteriosclerosis obliterans of lower limbs with syndrome of blood stasis and heat in the collaterals,and its clinical effect is significan

关 键 词：下肢动脉硬化闭塞症 顾步汤 脉络瘀热证 

分 类 号：R543.5[医药卫生—心血管疾病]