维生素D抗感染机制及相关疾病的研究进展  

Research progress on vitamin D anti-infection mechanism and related diseases

作　　者：林锐航 刘俊祥[2] LIN Ruihang;LIU Junxiang(Ordos School of Clinical Medicine,Inner Mongolia Medical University,Inner Mongolia Autonomous Region,Ordos017000,China;Department of Endocrinology,Ordos Central Hospital,Inner Mongolia Autonomous Region,Ordos017000,China)

机构地区：[1]内蒙古医科大学鄂尔多斯临床医学院,内蒙古鄂尔多斯017000 [2]内蒙古自治区鄂尔多斯市中心医院内分泌科,内蒙古鄂尔多斯017000

出　　处：《中国当代医药》2023年第32期36-39,共4页China Modern Medicine

摘　　要：维生素D作为一种脂溶性维生素,在调节骨代谢及钙离子方面深受国内外学者重视。但随着近些年多项系统评价和大量的观察性研究显示,维生素D缺乏与感染性疾病发病及发展存在密切相关性,具有活性的维生素D通过维生素D结合蛋白与相应受体可触发一系列免疫反应,包括对抗菌肽、单核细胞/巨噬细胞、T细胞与B细胞等的激活引起相关信号通路达到抗感染的作用。本文通过对维生素D受体(VDR)-抗菌肽轴、先天性免疫、适应性免疫等几方面对其抗感染机制进行阐述,同时对其相关病毒性感染性及细菌性感染等疾病进行综述。旨在探讨维生素D水平与感染性疾病的研究现状,虽然目前大量研究证实维生素D与感染性疾病存在相应联系,但仍缺乏其他感染性疾病充实相关数据。As a fat-soluble vitamin,vitamin D has been deeply valued by scholars at home and abroad in regulating bone metabolism and calcium ions,but with a number of systematic reviews and a large number of observational studies in recent years,vitamin D deficiency is closely related to the onset and development of infectious diseases,and active vitamin D can trigger a series of immune responses through vitamin D-binding proteins and corresponding receptors,including the activation of antibacterial peptides,monocytes/macrophages,T cells and B cells to cause related signaling pathways to achieve anti-infection.In this paper,the anti-infection mechanism of vitamin D receptors(VDR)-antimicrobial peptide axis,innate immunity and adaptive immunity is elaborated,and its related viral infectious and bacterial infections are reviewed.To explore the current status of research on vitamin D levels and infectious diseases,although a large number of studies have confirmed the corresponding association between vitamin D and infectious diseases,there is still a lack of data on other infectious diseases.

关 键 词：维生素D 感染性疾病 抗感染 抗菌肽 

分 类 号：R977.24[医药卫生—药品]