深圳市龙华区老年糖尿病患者血糖水平与肝肾功能的相关性研究  

Correlation study between blood glucose level and liver and kidney function in elderly diabetic patients in Longhua District of Shenzhen City

作　　者：张俭 ZHANG Jian(General Medicine,the People's Hospital of Longhua,Shenzhen,Guangdong Province,Shenzhen518000,China)

机构地区：[1]深圳市龙华区人民医院全科医学,广东深圳518000

出　　处：《中国当代医药》2023年第31期82-85,90,共5页China Modern Medicine

基　　金：广东省深圳市龙华区医疗卫生机构科研项目(2020111)。

摘　　要：目的研究深圳市龙华区老年糖尿病患者血糖水平与肝肾功能的相关性。方法选取深圳市龙华区人民医院2018年4月至2021年4月的300例60岁以上糖尿病患者作为研究对象,根据患者体重指数调整年龄、文化程度等混杂因素后,根据体重指数分为肥胖组(n=112)、超重组(n=78)、对照组(n=70)和营养不良组(n=40)。比较四组患者的血压值(舒张压和收缩压)、血糖值(空腹血糖和餐后2 h血糖)、肾功能(肌酐、尿素氮、尿白蛋白)、肝功能(转氨酶和白蛋白),并分析糖尿病患者血糖与肝肾指标的相关性,记录四组患者在期间出现的不良事件。结果肥胖组和超重组患者收缩压、舒张压、空腹血糖、肌酐、尿素氮、尿白蛋白、转氨酶和白蛋白均高于对照组和营养不良组患者,餐后2 h血糖低于对照组和营养不良组患者,差异有统计学意义(P<0.05);肥胖组患者收缩压、舒张压、空腹血糖、肌酐、尿素氮、尿白蛋白、转氨酶和白蛋白均高于超重组患者,餐后2 h血糖低于超重组患者,差异有统计学意义(P<0.05);通过Pearson相关性分析发现,糖尿病患者空腹血糖与肌酐、尿素氮、尿白蛋白、转氨酶和白蛋白水平呈正相关(r=0.314、0.431、0.397、0.376、0.384,P<0.05);四组患者的并发症或合并症总发生率比较,差异有统计学意义(P<0.05)。其中,肥胖组不良事件总发生率高于超重组、对照组、营养不良组,差异有统计学意义(P<0.008);超重组不良事件总发生率高于对照组、营养不良组,差异有统计学意义(P<0.008)。结论深圳市龙华区老年糖尿病患者血糖控制率和靶器官存在一定关系,并且肥胖程度越高以及血糖控制率越差的患者靶器官功能损伤越明显。Objective To investigate the correlation between blood glucose level and liver and kidney function in elderly diabetic patients in Longhua District of Shenzhen City.Methods A total of 300 diabetic patients over 60 years old in the People's Hospital of Longhua,Shenzhen,from April 2018 to April 2021 were selected as the research objects.After adjusting for confounding factors such as age and education level according to the body mass index of the patients,they were divided into obesity group(n=112),overweight group(n=78),control group(n=70)and malnutrition group(n=40).The blood pressure(diastolic blood pressure and systolic blood pressure),blood glucose(fasting blood glucose and 2 h postprandial blood glucose),renal function(creatinine,urea nitrogen,urine albumin),liver function(transaminase and albumin)of the four groups were compared,and the correlation between blood glucose and liver and kidney indexes in diabetic patients was analyzed.The adverse events of the four groups were recorded.Results The systolic blood pressure,diastolic blood pressure,fasting blood glucose,creatinine,urea nitrogen,urine albumin,transaminase and albumin in the obesity group and overweight groups were higher than those in the control group and the malnutrition group,and the 2-hour postprandial blood glucose was lower than that in the control group and the malnutrition group,and the differences were statistically significant(P<0.05).The systolic blood pressure,diastolic blood pressure,fasting blood glucose,creatinine,urea nitrogen,urine albumin,transaminase and albumin in the obesity group were higher than those in the overweight group,and the 2-hour postprandial blood glucose was lower than that in the overweight group,and the differences were statistically significant(P<0.05).Pearson correlation analysis showed that fasting blood glucose was positively correlated with creatinine,urea nitrogen,urine albumin,transaminase and albumin levels in diabetic patients(r=0.314,0.431,0.397,0.376,0.384,P<0.05).total incidence of adverse events in

关 键 词：糖尿病 血糖 靶器官损伤 相关性 

分 类 号：R587.1[医药卫生—内分泌]