Luminescent nano-bioprobes based on NIR dye/lanthanide nanoparticle composites  

作　　者：Shan Lu Jianxi Ke Xingjun Li Datao Tu Xueyuan Chen 

机构地区：[1]CAS Key Laboratory of Design and Assembly of Functional Nanostructures,and Fujian Key Laboratory of Nanomaterials,Fujian Institute of Research on the Structure of Matter,Chinese Academy of Sciences,Fujian,China [2]Fujian Science&Technology Innovation Laboratory for Optoelectronic Information of China,Fujian,China

出　　处：《Aggregate》2021年第5期115-131,共17页聚集体（英文）

基　　金：Science andTechnologyCooperation Fund between Chinese and AustralianGovernments,Grant/Award Number:2017YFE0132300;Strategic Priority Research Program of the CAS,Grant/Award Number:XDB20000000;NSFC,Grant/Award Numbers:51672272,21771185,21771178,21975257,12074380;Youth Innovation Promotion Association of CAS,Grant/Award Number:2017347。

摘　　要：Near-infrared(NIR)light,which has ignorable tissue scattering/absorption,minimal photodamage,and no autofluorescence interference,is highly favorable for bioapplications.NIR dye and lanthanide-doped nanoparticle(LnNP),as representative NIR-excited luminescence probes,have attracted increasing interest due to their unique optical property and low biological toxicity.Design of luminescence probes based on NIR dye/LnNP nanocomposites cannot only integrate the advantages but also achieve additional functions via regulating internal energy transfer pathways.In this review,we focus on the most recent advances in the development of NIR dye/LnNP nanocomposites as potential bioprobes,which cover from their fundamental photophysics to bioapplications,including energy transfer mechanisms,interface engineering(involving binding interaction,distance,and aggregation as key factors),and their applications for dye-sensitized upconversion/downshifting luminescent bioimaging,detection of biomolecules,and NIR-triggered diagnosis and therapy.Some future prospects and efforts toward this active research field are also envisioned.

关 键 词：dye sensitization energy transfer interface engineering lanthanide-doped nanoparticle nano-bioprobe NIR dye 

分 类 号：TB3[一般工业技术—材料科学与工程]