AIE-based drug/gene delivery system:Evolution from fluorescence monitoring alone to augmented therapeutics  

作　　者：Jie Sun Xuewen He 

机构地区：[1]The Key Lab of Health Chemistry and Molecular Diagnosis of Suzhou,College of Chemistry,Chemical Engineering and Materials Science,Soochow University,Suzhou,China

出　　处：《Aggregate》2022年第6期60-71,共12页聚集体（英文）

基　　金：the National Science Foundation of China,Grant/Award Numbers:22274106,22104104;startup funds from Soochow University;the Natural Science Foundation of Jiangsu Province,Grant/Award Number:BK20210701。

摘　　要：The aggregation-induced emission luminogens(AIEgens)with unique photophysical properties propel the rapid development of novel delivery systems for drugs and genes.In this review,we first presented numeral classic types of delivery systems based on light-up AIEgens for real-time monitoring of the delivery processes and evaluation of therapeutic outcomes of delivered drugs or genes.Next,general strategies were discussed for the delicately structural design of AIEgens that can self-assemble into bright therapeutic carriers through covalent or noncovalent interactions.Furthermore,given the unprecedented enhancements in therapeutic effects through the use of multimodes of therapy,AIEgens that were endowed with multiproperties and functionalities were investigated in the constructions of delivery systems for multimodality therapy.Especially,the combinational uses of AIE photosensitizers with chemo drug and small interference RNA(siRNA)were given as examples of augmenting the therapeutic performance in drug-resistant treatment and moderate immunotherapy by showing synergistic effects.

关 键 词：aggregation-induced emission combinational therapy delivery systems fluorescence imaging SELFASSEMBLY 

分 类 号：R95[医药卫生—药学]