Boost photothermal theranostics via self-assembly-induced crystallization(SAIC)  

作　　者：Xueluer Mu Fapu Wu Ying Tang Rui Wang Yajie Li Kaixuan Li Chunfeng Li Yingxi Lu Xianfeng Zhou Zhibo Li 

机构地区：[1]Key Lab of Biobased Polymer Materials of Shandong Provincial Education Department,College of Polymer Science and Engineering,Qingdao University of Science and Technology,Qingdao,P.R.China [2]College of Material Science and Engineering,Qingdao University of Science and Technology,Qingdao,P.R.China [3]College of Chemical Engineering,Qingdao University of Science and Technology,Qingdao,P.R.China

出　　处：《Aggregate》2022年第5期194-204,共11页聚集体（英文）

基　　金：National Natural Science Foundation of China,Grant/Award Numbers:22071128,51773107,51690152;Taishan Scholars Project of Shandong Province,Grant/Award Number:tsqn201812072;Major Scientific and Technological In-novation Projects of key R&D programs in Shandong Province,Grant/Award Number:2019JZZY021007;Shan-dong Provincial Natural Science Foundation,Grant/Award Number:ZR2020ZD31。

摘　　要：Owing to the intrinsic advantages of spatiotemporal selectivity,photothermal theranostics have become the advancing edge of precision medicine for cancer.Developing photothermal transduction agents(PTAs)with near-infrared(NIR)absorption,high photothermal conversion efficiency,robust photothermal stability,and good accumulation in tumors,is particularly valuable.Herein,we report a new concept,self-assembly-induced crystallization(SAIC),which can serve as a mechanism that dramatically boosts photothermal behaviors of PTA in NIR region.As a proof of concept,three heptamethine cyanine molecules with internal degrees of freedom(geometry and intramolecular interaction)are designed to fine-tune their crystallinity.Notably,Cy7-TCF-EMBI molecules with rigid and planar skeletons self-assemble into a crystalline state to maximize their packing density and improve the charge transfer,both of which contribute to nonradiative decay for energy dissipation as heat.The high packing density also renders an ideal scaffold for controlling intermolecular interactions to exhibit better photothermal stability,and endows an anisotropic three-dimensional architecture for passive tumor targeting.This“SAIC”strategy may offer a conceptually novel,practically simple but effective approach to unveil the structure–property relationship that could provide some general rules in rational design of PTAs,and paves the way for a next generation of supramolecular medicine for photothermal theranostics.

关 键 词：crystallization photothermal theranostic SELF-ASSEMBLY small molecule supramolecular medicine 

分 类 号：O17[理学—数学]