磷酰胆碱仿生聚合物的制备及应用研究  

Preparation and Application of Phosphoacylcholine Biomimetic Polymer

作　　者：叶非华 余泽彦 陈志胜 黄云薇 Ye Feihua;Yu Zeyan;Chen Zhisheng;Huang Yunwei(School of Environmental and Chemical Engineering,Zhaoqing University,Zhaoqing 526061;Provincial Key Laboratory of Environmental Health and Land Resource,Zhaoqing University,Zhaoqing 526061,China)

机构地区：[1]肇庆学院环境与化学工程学院,广东肇庆526061 [2]广东省环境健康与资源利用重点实验室,广东肇庆526061

出　　处：《广东化工》2023年第22期21-23,11,共4页Guangdong Chemical Industry

基　　金：大学生创新创业训练计划项目(S202110580068);高校教师特色创新研究项目(2021JNHB15);肇庆学院校级科研基金项目(QN202229);广东省环境健康与资源利用重点实验室编号(2020B121201014)。

摘　　要：通过聚合反应制备了含有2-甲基丙烯酰氧基乙基磷酰胆碱(MPC)组分的聚合物,将该聚合物涂覆在中空纤维膜表面可形成具有生物相容性的聚合物涂层,从而改善中空纤维膜表面的血液相容性。溶胀度测试表明聚合物具有良好的亲水性能。ATR-FTIR、XPS和SEM表明中空纤维膜表面形成了聚合物涂层。荧光测试能够快速的检测出涂层。血液相容性测试结果显示聚合物涂层能够降低中空纤维膜材料表面的血小板黏附和血栓残留,改善中空纤维膜表面的血液相容性。The polymer containing 2-methylacryloxyethyl phosphocholine(MPC)was prepared by polymerization reaction.The biocompatible polymer coating was formed on the surface of hollow fiber membrane,so as to improve the blood compatibility on the surface of hollow fiber membrane.The swelling test shows that the polymer has good hydrophilicity.ATR-FTIR,XPS and SEM analysis showed that polymer coating was formed on the surface of the hollow fiber membrane.Fluorescence testing can quickly detect the coatings.The blood compatibility test results showed that the polymer coating could reduce the adhesion of platelet and thrombus residue on the surface of hollow fiber membrane material,and improve the blood compatibility on the surface of hollow fiber membrane.

关 键 词：磷酰胆碱 聚合物 涂层 中空纤维膜 血液相容性 

分 类 号：TQ316.6[化学工程—高聚物工业]