天津地区境外输入新型冠状病毒肺炎(COVID-19)病例中药汤剂用药规律分析  

Herbal prescription rule of traditional Chinese medicine in treatment of imported COVID-19 cases in Tianjin

作　　者：张慧琪[1,2] 谢云雪 刘旻 赵启亮[1,2] 范爽 陈明虎[1,2] 刘春荣 刘奉云 蔡文欣[1,2,3] 安然 ZHANG Huiqi;XIE Yunxue;LIU Min;ZHAO Qiliang;FAN Shuang;CHEN Minghu;LIU Chunrong;LIU Fengyun;CAI Wenxin;AN Ran(First Teaching Hospital of Tianjin University of Traditional Chinese Medicine,Tianjin 300381,China;National Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion,Tianjin 300381,China;Tianjin University of Traditional Chinese Medicine,Tianjin 301617,China;Tianjin Haihe Hospital,Tianjin 300350,China)

机构地区：[1]天津中医药大学第一附属医院,天津300381 [2]国家中医针灸临床医学研究中心,天津300381 [3]天津中医药大学,天津301617 [4]天津市海河医院,天津300350

出　　处：《药物评价研究》2023年第10期2214-2221,共8页Drug Evaluation Research

基　　金：天津市卫生健康委、天津市中医药管理局中医、中西医结合科研课题(2021098)。

摘　　要：目的总结天津地区境外输入新型冠状病毒肺炎(COVID-19)病例中医汤剂用药规律。方法回顾性选择2019年12月—2021年5月天津市海河医院收治的境外输入轻型/普通型COVID-19病例,纳入中医治疗有效的病例为研究对象,建立数据库,录入患者一般资料、临床症状、中药处方等数据,采用数据挖掘方法,归纳中药使用频次、高频中药药对和药簇、中医聚类处方。结果纳入患者224例,中药汤剂处方224首,涉及中药148味,高频中药35味,药性温(1730次,41.79%)、药味苦(2433次,39.23%)、入肺经(3094次,30.19%)、清热药(990次,23.93%)和化痰止咳平喘药(807次,19.51%)使用频次最多;茯苓+陈皮、半夏+陈皮和虎杖+陈皮是常见的药对;茯苓+陈皮+虎杖和半夏+陈皮+虎杖是常见的角药;得出6组中药药簇和6类中医聚类处方。结论初步归纳出6类药簇和6个聚类处方,用于COVID-19各型各证的选方和加减,为中医治疗COVID-19提供临床选方用药参考。Objective To summarize the herbal prescription rule of traditional Chinese medicine in treatment of imported COVID-19 cases in Tianjin.Methods From December 2019 to May 2021,the light/ordinary COVID-19 cases imported from abroad were selected as the research objects,and the cases that were effectively treated by traditional Chinese medicine were included.A database was established,and data such as patients'general information,clinical symptoms and prescriptions of traditional Chinese medicine were entered.By using data mining methods,the frequency of use of traditional Chinese medicine,high-frequency pairs and clusters of traditional Chinese medicine and prescriptions of traditional Chinese medicine were summarized.Results Totally 224 patients were included,and there were 224 treatment prescriptions,involving 148 kinds of Chinese materia medica,35 kinds of highfrequency Chinese materia medica.The Chinese materia medica were mild in nature(1730 times,41.79%),bitter in taste(2433 times,39.23%),entering the lung meridian(3094 times,30.19%),clearing heat(990 times,23.93%)and resolving phlegm,relieving cough and relieving asthma(807 times,19.51%).Poria cocos+Pericarpium Citri Tangerinae,Pinellia ternata+Pericarpium Citri Tangerinae and Polygonum Cuspidatum+Pericarpium Citri Tangerinae are common drug pairs.Poria cocos+Pericarpium Citri Tangerinae+Polygonum Cuspidatum and Pinellia ternata+Pericarpium Citri Tangerinae+Polygonum Cuspidatum are common horn drugs.Six groups of traditional Chinese medicine clusters and six kinds of traditional Chinese medicine cluster prescriptions were obtained.Conclusion Six cluster prescriptions were preliminarily summarized,which were used for the selection,addition and subtraction of each syndrome of COVID-19,and provided clinical reference for the treatment of COVID-19 by traditional Chinese medicine.

关 键 词：新型冠状病毒肺炎 新型冠状病毒 境外输入 数据挖掘 中医药治疗 

分 类 号：R974[医药卫生—药品]