白藜芦醇抗肺癌作用及其机制的研究进展  

Research advance in pharmacologic effect and mechanism of resveratrol against lung cancer

作　　者：房立源 王润兮 方宇航 张英[1] FANG Liyuan;WANG Runxi;FANG Yuhang;ZHANG Ying(Department of Oncology,Guang'anmen Hospital,China Academy of Chinese Medical Sciences,Beijing 100053,China;Graduate School of Beijing University of Chinese Medicine,Beijing 100029,China)

机构地区：[1]中国中医科学院广安门医院肿瘤科,北京100053 [2]北京中医药大学研究生院,北京100029

出　　处：《药物评价研究》2023年第10期2277-2283,共7页Drug Evaluation Research

基　　金：国家中医药管理局中医药传承创新团队资助项目(ZYYCXTD-C-202205);中国中医药循证医学中心“业务研究室主任专项”。

摘　　要：白藜芦醇是天然化合物,属于非黄酮类的多酚化合物,存在于多种植物中,表现出良好的抗肺癌作用。白藜芦醇可以通过阻滞细胞周期、调控基因表达、抑制无氧糖酵解和干扰相关信号通路转导等方面抑制肿瘤细胞增殖;通过下调金属蛋白酶(ADAM)、基质金属蛋白酶(MMP)等抑制肿瘤细胞侵袭和迁移、通过下调血管内皮生成因子(VEGF)抗肿瘤血管生成、通过激活死亡受体途径和线粒体受体途径诱导肿瘤细胞凋亡和自噬、通过抑制耐药基因逆转靶向药物耐药和增强化疗药物敏感性而发挥抗肺癌活性。系统梳理了国内外有关白藜芦醇抗肺癌药理作用及其机制的研究进展,为抗肺癌新药研发提供参考。Resveratrol is a natural compound,which belongs to the non flavonoid polyphenol compound.It exists in a variety of plants and shows a good anti lung cancer effect.Resveratrol can inhibit the proliferation of tumor cells by blocking cell cycle,regulating gene expression,inhibiting anaerobic glycolysis and interfering with related signal pathway transduction.It can inhibit tumor cell invasion and migration by down-regulation of metalloproteinases(ADAM),matrix metalloproteinase(MMP),etc.Resveratrol can inhibit tumor angiogenesis by down-regulation of vascular endothelial growth factor(VEGF).It can induce the tumor cell apoptosis and autophagy by activation of death receptor pathway and mitochondrial receptor pathway.It can reverse targeted drug resistance by inhibition of drug resistance genes,and enhance chemotherapy drug sensitivity.This article systematically reviewed the research progress of resveratrol's pharmacological action and mechanism against lung cancer at home and abroad,providing a reference for the development of new drug development against lung cancer.

关 键 词：白藜芦醇 肺癌 凋亡和自噬 细胞增殖 血管生成 

分 类 号：R285.5[医药卫生—中药学]