SAA/CRP、hs-CRP及WBC联合检测对小儿社区获得性肺炎的临床诊断价值  

Clinical Diagnostic Value of Combined Detection of SAA/CRP,hs-CRP and WBC in Children with Community Acquired Pneumonia

作　　者：宁建凤 聂小梅 NING Jianfeng;NIE Xiaomei(Clinical Laboratory,Nanfeng County People's Hospital,Fuzhou 344500,China;Clinical Laboratory,Nanfeng Maternal and Child Health Hospital,Fuzhou 344500,China)

机构地区：[1]南丰县人民医院检验科,江西抚州344500 [2]南丰县妇幼保健院检验科,江西抚州344500

出　　处：《临床医学工程》2023年第11期1535-1536,共2页Clinical Medicine & Engineering

摘　　要：目的探讨血清淀粉样蛋白A(SAA)/C反应蛋白(CRP)、超敏C反应蛋白(hs-CRP)及白细胞(WBC)联合检测对小儿社区获得性肺炎(CAP)的临床诊断价值。方法选取2020年1月至2022年1月收治的80例CAP患儿作为研究组,根据病情严重程度将其分为重症组(n=32)和非重症组(n=48)两个亚组,另选取同期50名健康体检儿童作为对照组。比较研究组和对照组、重症组和非重症组的SAA/CRP、hs-CRP及WBC水平,分析SAA/CRP、hs-CRP及WBC联合检测对CAP的诊断效能。结果研究组SAA/CRP、hs-CRP及WBC水平均高于对照组(P<0.05);重症组SAA/CRP、hs-CRP及WBC水平高于非重症组(P<0.05)。SAA/CRP、hs-CRP及WBC联合检测诊断CAP的曲线下面积(AUC)为0.942,预测灵敏度、特异度分别为90.2%、84.5%,高于上述各指标单独检测。结论SAA/CRP、hs-CRP及WBC在小儿CAP中表达水平升高且与病情进展密切相关,各指标联合检测诊断小儿CAP价值较高。Objective To explore the clinical diagnostic value of combined detection of serum amyloid A(SAA)/C-reactive protein(CRP),hypersensitive C-reactive protein(hs-CRP),and white blood cells(WBC)in children with community acquired pneumonia(CAP).Methods 80 CAP children from January 2020 to January 2022 were selected as the study group,and divided into severe group(n=32)and non-severe group(n=48)according to the disease severity.Another 50 healthy children were selected as the control group.The SAA/CRP,hs-CRP and WBC levels were compared between the study group and the control group,and the severe group and the non severe group.The diagnostic efficacy of combined detection of SAA/CRP,hs-CRP and WBC in CAP was analyzed.Results The SAA/CRP,hs-CRP and WBC levels of the study group were higher than those of the control group(P<0.05).The SAA/CRP,hs-CRP and WBC levels of the severe group were higher than those of the non-severe group(P<0.05).The area under curve(AUC)of combined detection of SAA/CRP,hs-CRP and WBC in the diagnosis of CAP was 0.942,with predictive sensitivity and specificity of 90.2%and 84.5%,respectively,which were higher than those of single detection of the above indicators.Conclusions SAA/CRP,hs-CRP and WBC in CAP children are highly expressed and closely related to the disease progression.The combined detection of the indicators is of high value in the diagnosis of CAP children.

关 键 词：小儿社区获得性肺炎 SAA/CRP HS-CRP WBC 诊断价值 

分 类 号：R725.6[医药卫生—儿科]